Hock cleavage of cholesterol 5alpha-hydroperoxide: an ozone-free pathway to the cholesterol ozonolysis products identified in arterial plaque and brain tissue.
Hock cleavage of cholesterol 5alpha-hydroperoxide: an ozone-free pathway to the cholesterol ozonolysis products identified in arterial plaque and brain tissue.
复制标题
胆固醇 5α-氢过氧化物的飞节裂解：动脉斑块和脑组织中发现的胆固醇臭氧分解产物的无臭氧途径。
DOI：
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发表时间：
2008
影响因子：
15
通讯作者：
D. Pratt
中科院分区：
文献类型：
--
作者：
J. Brinkhorst;S. Nara;D. Pratt
Cholesterol 5alpha-hydroperoxide, the major product of 1O2-oxidation of cholesterol, readily undergoes acid-catalyzed (Hock) cleavage of the C5-C6 bond to yield the 5,6-secosterol ketoaldehyde and the product of its intramolecular aldolization. These cholesterol oxidation products have long been thought to arise solely from ozonolysis of cholesterol, prompting the recent suggestion that ozone is produced in humans following their identification in arterial and brain tissue extracts.
