Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma.
Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma.
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DOI：
10.1016/j.lrr.2022.100305
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发表时间：
2022
影响因子：
--
通讯作者：
Mitani K
中科院分区：
文献类型：
--
作者：
Nakamura F;Nakamura Y;Nannya Y;Arai H;Shimbo K;Nakamura Y;Seo S;Sasaki K;Ichikawa M;Ogawa S;Mitani K
一名65岁男性非重型再生障碍性贫血患者接受兔抗胸腺细胞球蛋白和环孢霉素治疗，部分缓解。开始治疗6个月后，他被诊断为IV期血管免疫母细胞性T细胞淋巴瘤并接受化疗。PET/CT扫描分析显示完全缓解。然而，他表现出持续的骨髓抑制，并被诊断为再生障碍性贫血复发。他对环孢菌素、艾曲泊帕或美替诺龙无反应。艾曲泊帕给药后15个月，患者发生MDS伴t（3;21）（q26.2;q22）。在艾曲泊帕治疗期间和治疗后，应仔细监测患者是否出现-7/del（7 q）和3q 26异常，包括t（3;21）（q26.2;q22）。
A 65-year-old man with nonsevere aplastic anemia received rabbit anti-thymocyte globulin and cyclosporine and partially responded. Six months after the initiation of treatment, he was diagnosed with stage IV angioimmunoblastic T-cell lymphoma and received chemotherapy. PET/CT scan analysis indicated a complete response. However, he showed sustained myelosuppression and was diagnosed with relapse of aplastic anemia. He did not respond to cyclosporine, eltrombopag or methenolone. Fifteen months after eltrombopag administration, he developed MDS with t(3;21)(q26.2;q22). Patients should be monitored carefully for the emergence of not only -7/del(7q) but also 3q26 abnormalities, including t(3;21)(q26.2;q22), during and after eltrombopag treatment.
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艾曲波帕和改善难治性再生障碍性贫血的造血功能。
DOI：
10.1056/nejmoa1200931
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Olnes MJ;Scheinberg P;Calvo KR;Desmond R;Tang Y;Dumitriu B;Parikh AR;Soto S;Biancotto A;Feng X;Lozier J;Wu CO;Young NS;Dunbar CE
通讯作者：
Dunbar CE
影响因子：
11.4
作者：
MITANI, K;OGAWA, S;HIRAI, H
通讯作者：
HIRAI, H
DOI：
10.1056/nejmoa1613878
发表时间：
2017-04-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Townsley DM;Scheinberg P;Winkler T;Desmond R;Dumitriu B;Rios O;Weinstein B;Valdez J;Lotter J;Feng X;Desierto M;Leuva H;Bevans M;Wu C;Larochelle A;Calvo KR;Dunbar CE;Young NS
通讯作者：
Young NS
影响因子：
20.3
作者：
Greenberg, Peter L.;Tuechler, Heinz;Haase, Detlef
通讯作者：
Haase, Detlef
影响因子：
20.3
作者：
Desmond, Ronan;Townsley, Danielle M.;Dunbar, Cynthia E.
通讯作者：
Dunbar, Cynthia E.