The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons
The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons
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DOI：
10.1016/j.jneuroim.2004.07.009
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Gruol, DL
中科院分区：
文献类型：
--
作者：
Nelson, TE;Gruol, DL
在这项研究中，我们提供了趋化因子 CXCL10 对原代培养物中海马神经元生理学的直接调节作用的证据。 CXCL10 引起细胞内 Ca2+ 升高，并增强海马神经元的自发电活动和诱发电活动。 CXCL10 诱导的细胞内 Ca2+ 升高与神经元放电的增加以及诱发 Ca2+ 信号和神经元活动之间关系的改变有关。 CXCL10 的影响并不伴随静息膜电位 (RMP) 或输入电阻的变化。 CXCR3 趋化因子受体的表达支持 CXCL10 对海马神经元的直接作用。 (C) 2004 Elsevier B.V. 保留所有权利。
In this study, we provide evidence for direct modulatory effects of the chemokine, CXCL10, on the physiology of hippocampal neurons maintained in primary culture. CXCL10 elicited a rise in intracellular Ca2+ and enhanced both spontaneous and evoked electrical activity of hippocampal neurons. CXCL10-induced elevations in intracellular Ca2+ were associated with an increase in neuronal firing and an alteration in the relationship between the evoked Ca2+ Signal and neuronal activity. The effects of CXCL10 were not accompanied by a shift in resting membrane potential (RMP) or input resistance. Expression of the CXCR3 chemokine receptor supports a direct effect of CXCL10 on hippocampal neurons. (C) 2004 Elsevier B.V. All rights reserved.