Effects of dietary carbohydrate on delayed onset muscle soreness and reactive oxygen species after contraction induced muscle damage
Effects of dietary carbohydrate on delayed onset muscle soreness and reactive oxygen species after contraction induced muscle damage
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DOI：
10.1136/bjsm.2005.019844
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发表时间：
2005-12-01
影响因子：
18.4
通讯作者：
MacLaren, DPM
中科院分区：
文献类型：
--
作者：
Close, GL;Ashton, T;MacLaren, DPM
背景资料：迟发性肌肉酸痛（DOMS）发生在不习惯的运动后，并已被认为是由于活性氧（ROS）。先前的研究表明，延长收缩后增加的ROS，可归因于入侵的吞噬细胞。血浆葡萄糖是吞噬细胞的重要燃料，因此运动前的碳水化合物（CHO）状态可能影响ROS产生和DOMS Objective：为了检查运动前CHO状态对DOMS、ROS产生和收缩诱导的肌肉损伤后的肌肉功能的影响，方法：12名受试者进行了两次下坡跑，一次在高CHO饮食后，一次在低CHO饮食后。抽取血液样本用于分析丙二醛、总谷胱甘肽、肌酸激酶、非酯化脂肪酸、乳酸盐、葡萄糖和白细胞。结果：高胆固醇饮食组运动前呼吸交换率和乳酸浓度均高于低胆固醇饮食组。低CHO饮食导致运动前较高的非酯化脂肪酸浓度。DOMS在运动后发展，并在两种饮食后保持长达96小时。在运动后24和96小时，两种饮食后肌酸激酶发生双相反应。运动后72小时，两种饮食后，丙二醛增加，肌肉功能衰减到这个时间。结论：下坡运行导致增加的ROS生产和评级的DOMS和二次增加肌肉损伤。运动前的CHO状态没有影响。
Background: Delayed onset muscle soreness ( DOMS) occurs after unaccustomed exercise and has been suggested to be attributable to reactive oxygen species ( ROS). Previous studies have shown increased ROS after lengthening contractions, attributable to invading phagocytes. Plasma glucose is a vital fuel for phagocytes, therefore carbohydrate ( CHO) status before exercise may influence ROS production and DOMSObjective: To examine the effect of pre- exercise CHO status on DOMS, ROS production, and muscle function after contraction induced muscle damage.Method: Twelve subjects performed two downhill runs, one after a high CHO diet and one after a low CHO diet. Blood samples were drawn for analysis of malondialdehyde, total glutathione, creatine kinase, non- esterified fatty acids, lactate, glucose, and leucocytes. DOMS and muscle function were assessed daily.Results: The high CHO diet resulted in higher respiratory exchange ratio and lactate concentrations than the low CHO diet before exercise. The low CHO diet resulted in higher non- esterified fatty acid concentrations before exercise. DOMS developed after exercise and remained for up to 96 hours, after both diets. A biphasic response in creatine kinase occurred after both diets at 24 and 96 hours after exercise. Malondialdehyde had increased 72 hours after exercise after both diets, and muscle function was attenuated up to this time.Conclusions: Downhill running resulted in increased ROS production and ratings of DOMS and secondary increases in muscle damage. CHO status before exercise had no effect.