Nitroprusside infusion improves arterial baroreflex control of heart rate in dogs with chronic congestive heart failure.
Nitroprusside infusion improves arterial baroreflex control of heart rate in dogs with chronic congestive heart failure.
复制标题
硝普钠输注可改善患有慢性充血性心力衰竭的狗的动脉压力反射对心率的控制。
DOI：
10.1097/00005344-199424050-00003
复制
发表时间：
1994
影响因子：
3
通讯作者：
HoodJr,WB
中科院分区：
文献类型：
--
作者：
Himura,Y;Liang,CS;Delehanty,JM;HoodJr,WB
为了确定硝普钠是否改善慢性充血性心力衰竭（CHF）的动脉压力感受性反射反应，我们给11只清醒的起搏诱导CHF犬注射硝普钠。压力反射敏感性通过绘制推注苯肾上腺素（PE）后RR间期对主动脉收缩压的曲线来确定。在基线时，与10只假手术正常动物相比，CHF犬的心率（HR）较高，左心房血压（BP）升高，左心室（LV）dP/dt降低。CHF犬的压力反射敏感性指数（8.3+/-1.3 ms/mm Hg）显著低于正常犬（25.1+/-1.2 ms/mm Hg，p< 0.001）。CHF犬静脉（iv）给予硝普钠（1 [mu] g/kg/min）可降低左心房BP（23+/-1-17+/-1 mm Hg）和HR（131+/-4-115+/-4次/分钟），但对心输出量（CO）或收缩期主动脉血压无显着影响。这导致压力反射敏感性指数增加58%，达到13.1+/-1.3 ms/mm Hg（p< 0.001）;该变化与左心房BP降低幅度显著相关（r= 0.884，p< 0.001），但与RR间期增加无关（r= 0.390，p> 0.10）。与此相反，在5只正常犬中，给予足以降低左房血压（9.0 ± 1.4 - 6.4 ± 1.2 mm Hg）的硝普钠并不改变压力反射敏感性（26.4 ± 3.4 - 26.4 ± 3.9 ms/mm Hg）。结果表明，硝普钠输注增加动脉压力感受器反射的敏感性，只有在狗与CHF，这种效果可能是功能性的心脏充盈压的降低。
To determine if nitroprusside improves arterial baroreflex responsiveness in chronic congestive heart failure (CHF), we administered nitroprusside to 11 conscious dogs with pacing-induced CHF. Baroreflex sensitivity was determined by plotting the RR interval against systolic aortic pressure after a bolus injection of phenylephrine (PE). At baseline, dogs with CHF had higher heart rate (HR), increased left atrial blood pressure (BP), and reduced left ventricular (LV) dP/dt as compared with 10 sham-operated normal animals. Baroreflex sensitivity index was significantly lower in CHF dogs,(8.3+/-1.3 ms/mm Hg) than normal dogs (25.1+/-1.2 ms/mm Hg, p< 0.001). Intravenous (iv) administration of nitroprusside (1 [mu] g/kg/min) to CHF dogs decreased left atrial BP (23+/-1-17+/-1 mm Hg) and HR (131+/-4-115+/-4 beats/min), but had no significant effect on either cardiac output (CO) or systolic aortic BP. This resulted in a 58% increase in baroreflex sensitivity index to 13.1+/-1.3 ms/mm Hg (p< 0.001); and the change correlated significantly with magnitude of decrease in left atrial BP (r= 0.884, p< 0.001) but not with the increase in RR interval (r= 0.390, p> 0.10). In contrast, administration of nitroprusside sufficient to decrease left atrial BP (9.0+/-1.4-6.4+/-1.2 mm Hg) did not alter baroreflex sensitivity (26.4+/-3.4-26.4+/-3.9 ms/mm Hg) in 5 normal dogs. The results suggest that nitroprusside infusion increases arterial baroreflex sensitivity only in dogs with CHF and that this effect is probably functionally linked to the reductions of cardiac filling pressure.