Chiral N,N '-Dioxide/Lanthanide(III) Complex Catalyzed Asymmetric Bisvinylogous Mukaiyama Aldol Reactions
Chiral N,N '-Dioxide/Lanthanide(III) Complex Catalyzed Asymmetric Bisvinylogous Mukaiyama Aldol Reactions
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DOI：
10.1021/acs.orglett.6b03470
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Feng Xiaoming
中科院分区：
文献类型：
--
作者：
Fu Kai;Zhang Jingchuan;Lin Lili;Li Jun;Liu Xiaohua;Feng Xiaoming
合成了手性N，N′-二氧化物/Y（OTf）3和Sc（OTf）3配合物催化硅基烯酮缩醛与α-酮酯和醛的双乙烯基Mukaiyama羟醛缩合反应。该催化体系具有较高的ε-选择性，底物范围广。相应的ε-羟基-α，β，γ，δ-不饱和酯的收率可达95%，ee值可达98%。
ChiralN,N′-dioxide/Y(OTf)3and Sc(OTf)3complexes have been developed as efficient catalysts for the bisvinylogous Mukaiyama aldol reaction of silyl ketene acetal with α-ketoesters and aldehydes, respectively. The catalytic systems were highly ε-selective, and the substrate scope was wide. The corresponding ε-hydroxy-α,β,γ,δ-unsaturated esters were obtained in up to 95% yield and 98% ee.