American Red Cross
American Red Cross
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美国红十字会
DOI：
--
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发表时间：
2007
影响因子：
2.7
通讯作者：
J. Mcguire
中科院分区：
文献类型：
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作者：
J. Mcguire
1947年，沃尔什和蒙哥马利以及雷斯和桑格首次描述了MNS 4血型抗原。它是MN血型系统的成员，该系统由40多种明确定义的离散抗原组成。抗-S抗体的例子通常是通过输血或怀孕对免疫的反应产生的，但也可以在没有明显刺激的人中看到。它们通常是IgG，在室温（18-28 ℃）或37 ℃下通过间接抗球蛋白试验（IAT）优先反应。一些在低于37 ℃的温度下反应的盐水反应性/IgM的例子也有报道。抗血清的例子通常不激活补体。据报道，抗链球菌抗体可引起输血反应和胎儿及新生儿溶血病（HDFN）。
The s ̅ (MNS4) blood group antigen was first described in 1947 by Walsh and Montgomery and by Race and Sanger. It is a member of the MN blood group system which consists of more than 40 well defined, discrete antigens. Examples of anti-s ̅ are usually produced in response to immunization by transfusion or pregnancy, but may be seen in persons without obvious stimulation. They are usually IgG in nature, reacting preferentially by the indirect antiglobulin test (IAT) at room temperature (18-28 C) or 37 C. Some salinereactive/IgM examples, reacting at temperatures below 37 C, have also been reported. Examples of anti-s ̅ do not usually activate complement. Anti-s ̅ has been reported to cause transfusion reactions and hemolytic disease of the fetus and newborn (HDFN).