Helicobacter pylori infection appears essential for stomach carcinogenesis: Observations in Semarang, Indonesia
Helicobacter pylori infection appears essential for stomach carcinogenesis: Observations in Semarang, Indonesia
复制标题
幽门螺杆菌感染似乎对胃癌的发生至关重要：在印度尼西亚三宝垄的观察
作者：
S. Tokudome;W. Samsuria;Soeripto;F. E. Triningsih;Sadao Suzuki;A. Hosono;Teguh Triono;I. Wijaya;Sarjadi;Ika P. Miranti;Reza Ghadimi;M. Moore
印度尼西亚塞马朗的胃癌发病率极低：仅为日本的1/100。为了阐明原因，我们在2005年1月进行了一项生态研究，从普通民众中招募了69名男性和102名女性参与者。男性和女性的尿素呼气试验阳性率均为0%，幽门螺杆菌（H。pylori）IgG抗体在2%（0-5，95%置信区间）的男性和2%（0-4）的女性中发现，显著低于日本的62%（58-65）和57%（53-60）。此外，塞马朗的胃蛋白酶原试验未发现阳性结果，与日本的23%（22-25）和22%（20-23）相比也具有显著性。吸烟水平和消费的NaCl，蔬菜和水果的变化被发现，但在一定程度上，将允许解释胃癌发病率的主要差异。我们可以得出结论，H.幽门螺杆菌感染和慢性萎缩性胃炎是印度尼西亚塞马朗胃癌罕见的原因。（Cancer Sci 2005; 96：873-875）
The gastric cancer incidence in Semarang, Indonesia, is exceedingly low: only approximately 1/100th of the level in Japan. To elucidate the reason, we carried out an ecological study recruiting 69 male and 102 female participants from the general populace in January 2005. Positive urea breath tests were 0% for both men and women, and Helicobacter pylori (H. pylori) IgG antibodies were found in 2% (0–5, 95% confidence interval) of men and 2% (0–4) of women, significantly lower than the 62% (58–65) and 57% (53–60), respectively, in Japan. Furthermore, there were no positive findings with the pepsinogen tests in Semarang, again significant in comparison with the 23% (22–25) and 22% (20–23) in Japan. Variation in smoking levels and consumption of NaCl, vegetables and fruit were found, but not to an extent that would allow explanation of the major differences in gastric cancer incidence. We may conclude that the very low prevalence of H. pylori infection and thus chronic atrophic gastritis account for the rarity of stomach cancer in Semarang, Indonesia. (Cancer Sci 2005; 96: 873–875)