Capabilities of a penetrating microelectrode array for recording single units in dorsal root ganglia of the cat
Capabilities of a penetrating microelectrode array for recording single units in dorsal root ganglia of the cat
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DOI：
10.1016/s0165-0270(03)00143-2
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发表时间：
2003-09-30
影响因子：
3
通讯作者：
Normann, RA
中科院分区：
文献类型：
--
作者：
Aoyagi, Y;Stein, RB;Normann, RA
在急性实验中研究了猫背根神经节（DRG）微电极阵列的记录能力，在587个电极（0.64个单位/电极）上记录了373个单个、可辨别的感觉单位。获得了高达1750 μ V的感觉动作电位（平均值= 132 μ V）。这些与文献报道的传统电极进行的最佳DRG细胞外记录相当。我们能够同时激活和记录超过50个可辨别的，时变单位从L 6和L7背根神经节在一个周期性踝关节移位。我们还成功地记录了稳定的，相位依赖的多个感觉单位，在去大脑行走过程中几乎没有伪影或肌电图（EMG）污染。因此，该阵列能够比传统记录技术更有效地记录更多的DRG神经元。阵列的记录选择性和稳定性，再加上大量的神经元，可以同时记录，提供有吸引力的功能，更好地理解感觉运动控制原理。(C)2003 Elsevier B. V.保留所有权利。
The recording capability of a microelectrode array in the cat dorsal root ganglion (DRG) was studied in I I acute experiments, 373 single, discriminable sensory units were recorded on 587 electrodes (0.64 units/electrode). Sensory action potentials as large as 1750 muV were obtained (mean = 132 muV). These were comparable to literature reports of the best DRG extracellular recordings made with conventional electrodes. We were able simultaneously to activate and record over 50 discriminable, time-varying units from L6 and L7 DRGs during a cyclic ankle displacement. We also successfully recorded stable, phase dependent multiple sensory units with very little artifact or electromyographic (EMG) contamination during decerebrate walking. Thus, the array is capable of recording more effectively from more DRGs neurons than has been achieved by conventional recording techniques. The recording selectivity and stability of the array, coupled with the large number of neurons that can be recorded simultaneously, provide attractive features for better understanding sensorimotor control principles. (C) 2003 Elsevier B.V. All rights reserved.