COURSE AND OUTCOME OF ACUTE CEREBELLAR-ATAXIA
COURSE AND OUTCOME OF ACUTE CEREBELLAR-ATAXIA
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DOI：
10.1002/ana.410350607
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发表时间：
1994-06-01
影响因子：
11.2
通讯作者：
RUST, RS
中科院分区：
文献类型：
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作者：
CONNOLLY, AM;DODSON, WE;RUST, RS
我们报告了一项针对 73 名患有急性小脑性共济失调的连续儿童的研究，代表了 23 年间在圣路易斯儿童医院接受评估的所有儿童，这些儿童可以适当地分配这种诊断。 26% 的人患有水痘，52% 的人患有其他被认为是病毒引起的疾病，3% 的人患有共济失调，与免疫接种有关。百分之十九没有明确的前驱症状。 60 名儿童在共济失调发作后接受了 4 个月或更长时间的随访（平均 7.4+/-6.0 年）。其中百分之九十一 (55/60)，包括所有患有水痘的儿童，都从共济失调中完全康复。百分之八十九 (39/44) 的非水痘相关共济失调儿童完全从共济失调中恢复，这比之前大型研究中发现的恢复率要高得多。在长达 4 个多月的随访中，五分之一的儿童出现了短暂的行为或智力困难，但 60 名儿童中只有 5 人表现出持续的学习问题。这项研究代表了最大的急性小脑性共济失调系列报道，也是对该疾病的临床特征和结果最完整的描述。
We report a study of 73 consecutive children with acute cerebellar ataxia, representing all of the children evaluated at St. Louis Children's Hospital during a 23-year-period to whom this diagnosis could appropriately be assigned. Twenty-six percent had chickenpox, 52% had other illnesses that were presumed to be viral, and in 3% the ataxia was related to immunization. Nineteen percent had no definite prodrome. Sixty children were followed for 4 months or longer after onset of their ataxia (mean, 7.4+/-6.0 years). Ninety-one percent (55/60) of these, including all children with chickenpox, recovered completely from ataxia. Eighty-nine percent (39/44) of the children with non-varicella-related ataxia recovered completely from the ataxia, a much better rate of recovery than what was found in prior large studies. One fifth of the children followed for more than 4 months experienced transient behavioral or intellectual difficulties, but only 5 of the 60 children demonstrated sustained learning problems. This study represents the largest reported series of acute cerebellar ataxia and the most complete characterization of the clinical features and outcome of this illness.