A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1
A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1
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DOI：
10.1046/j.1365-2141.1996.d01-1811.x
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发表时间：
1996-08-01
影响因子：
6.5
通讯作者：
Dore, JM
中科院分区：
文献类型：
--
作者：
Wijdenes, J;Vooijs, WC;Dore, JM
我们开发了一种新的单克隆抗体，B-B4，它特异性地识别人浆细胞。它与所有多发性骨髓瘤细胞系和与测试的多发性骨髓瘤患者的所有肿瘤样品的恶性浆细胞强烈反应。B-B4不与任何外周血，骨髓或扁桃体细胞反应。B-B4抗原的克隆揭示了单克隆抗体识别多配体蛋白聚糖-1。单克隆抗体B-B4是一种适合于在造血细胞中鉴定人浆细胞的标记物，也是一种诊断血液系统恶性肿瘤的有用探针。此外，该单克隆抗体可用于CD 34移植前的清除。
We developed a new monoclonal antibody, B-B4, which specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines and with malignant plasma cells of all tumour samples of the multiple myeloma patients tested. B-B4 does not react with any peripheral blood, bone marrow or tonsil cells. Cloning of the B-B4 antigen reveals that the monoclonal antibody recognizes syndecan-1. It appears that the monoclonal antibody B-B4 is a suitable marker for human plasmocyte identification among haemopoietic cells and a useful probe for the diagnosis of haematological malignancies. Furthermore, this monoclonal antibody can be used for depletions prior to CD34 grafting.