Clinicopathological and prognostic analyses of 86 resected pulmonary lymphoepithelioma-like carcinomas
Clinicopathological and prognostic analyses of 86 resected pulmonary lymphoepithelioma-like carcinomas
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86例切除肺淋巴上皮瘤样癌的临床病理学和预后分析
DOI：
10.1002/jso.26276
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发表时间：
2020-10-30
影响因子：
2.5
通讯作者：
Chen, Chang
中科院分区：
文献类型：
--
作者：
Chen, Jiafei;Gu, Chang;Chen, Chang
背景肺淋巴上皮瘤样癌（LELC）是一种罕见的原发性肺癌亚型。方法收集2008年12月至2018年12月我院收治的肺LELC患者，分析其手术切除后的临床病理特征及预后。结果86例患者中，男性39例（45.3%），女性47例（54.7%）。大部分血清肿瘤标志物正常。免疫组化染色结果显示上皮组织具有频繁分化的特征。PD-L1（15/19，78.9%）和PD-1（13/17，76.5%）阳性也很常见，但癌症相关基因突变很少（1/47，2.1%）。生存分析表明，N期（p = .011）和切除范围结论肺LELC是一种独特的肺癌亚型，具有多发生于不吸烟的年轻人、肿瘤分化为上皮样起源、免疫检查点表达频繁、和驱动突变的稀缺存在。肺LELC预后较好，尤其是早期诊断和治疗的病例。
Background Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare subtype of primary lung cancer. The present study aims at investigating clinicopathological features and prognostic characteristics of the resected pulmonary LELC.Methods Patients with resected pulmonary LELC were identified in our hospital from December 2008 to December 2018. Data of these patients were retrospectively reviewed, clinicopathological features and prognostic characteristics were analyzed subsequently.Results In total, 86 patients were enrolled in the study, including 39 (45.3%) males and 47 (54.7%) females. Most of the serum tumor markers were normal. Immunohistochemical staining result showed frequent differentiation traits of epithelial tissue such. Positive PD-L1 (15 of 19, 78.9%) and PD-1 (13 of 17, 76.5%) were also common, but cancer-related genetic mutation was scarce (1 of 47, 2.1%). Survival analyses demonstrated that the N stage (p = .011) and extent of resection (p = .023) were identified as independent predictive factors for overall survival.Conclusions Pulmonary LELC is a distinctive subtype of lung cancer with several exclusive traits, such as the trend to happen among nonsmoking young people, epithelial origin of tumor differentiation, frequent expression of the immune checkpoint, and scarce presence of driver mutation. In addition, pulmonary LELC was apt to get a favorable outcome, especially in cases diagnosed and treated in the early stage.