Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input
Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input
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DOI：
10.1016/s0306-4522(03)00570-0
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发表时间：
2003-01-01
期刊：
影响因子：
3.3
通讯作者：
Classey, JD
中科院分区：
文献类型：
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作者：
Goadsby, PJ;Classey, JD
5-羟色胺（5-HT（1B/1D））激动剂治疗偏头痛急性发作的研究引起了人们的极大兴趣。将上级矢状窦（SSS）分离于a-氯醛糖（60 mg/kg，i. p.和20 mg/kg i.v.i.）补充2小时）麻醉的猫。电刺激SSS（100 V，250 μ s持续时间，0.3 Hz），并使用电生理学方法监测三叉神经复合体的神经元。为了测试5-HT 1B受体介导的活性，用放置在血管周围的跨音速流动探针监测颈总动脉血流量（CCF）。那拉曲普坦（5-HT 1B/1D/1F受体激动剂）和阿尼地坦（5-HT 1B/1D受体激动剂）分别使颈动脉血流量减少38+/-5%和42+/-6%。5-HT 1B受体拮抗剂SB 224289可减弱上述作用（P
Development of serotonin (5HT(1B/1D)) agonists for the acute attack of migraine resulted in considerable interest in their action. The superior sagittal sinus (SSS) was isolated in a-chloralose (60 mg/kg, i.p. and 20 mg/kg i.v.i. supplementary 2 hourly) anaesthetised cats. The SSS was stimulated electrically (100 V, 250 mus duration, 0.3 Hz) and neurons of the trigeminocervical complex monitored using electrophysiological methods. To test 5-HT1B receptor-mediated activity common carotid blood flow (CCF) was monitored with a transonic flow probe placed around the vessel. Naratriptan (5-HT1B/1D/1F receptor agonist) and alniditan (5-HT1B/1D receptor agonist) produced reductions in carotid blood flow of 38+/-5% and 42+/-6%, respectively. These effects were attenuated by the 5-HT1B receptor antagonist SB224289 (P