Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates
Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates
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DOI：
10.1172/jci119755
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发表时间：
1997-11-01
影响因子：
15.9
通讯作者：
Buttrick, PM
中科院分区：
文献类型：
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作者：
Bowman, JC;Steinberg, SF;Buttrick, PM
蛋白激酶C （PKC）在心脏中的激活与肥厚表型和影响收缩功能的过程有关。为了确定PKC激活是否足以诱导异常表型，PKC β在转基因小鼠心肌细胞中有条件表达。成人中的转基因表达导致与舒张舒张受损相关的轻度和进行性心室肥厚，而新生儿中的转基因表达导致与细胞内钙调节明显异常相关的猝死。因此，心肌细胞中的PKC信号通路根据表达的时间有不同的作用，在成人中，PKC信号通路足以诱导病理性肥大。
Protein kinase C (PKC) activation in the heart has been linked to a hypertrophic phenotype and to processes that influence contractile function. To establish whether PKC activation is sufficient to induce an abnormal phenotype, PKC beta was conditionally expressed in cardiomyocytes of transgenic mice. Transgene expression in adults caused mild and progressive ventricular hypertrophy associated with impaired diastolic relaxation, whereas expression in newborns caused sudden death associated with marked abnormalities in the regulation of intracellular calcium. Thus, the PKC signaling pathway in cardiocytes has different effects depending on the timing of expression and, in the adult, is sufficient to induce pathologic hypertrophy.