EFFECTS OF NERVE COMPRESSION OR ISCHEMIA ON CONDUCTION PROPERTIES OF MYELINATED AND NON-MYELINATED NERVE-FIBERS - AN EXPERIMENTAL-STUDY IN THE RABBIT COMMON PERONEAL NERVE
EFFECTS OF NERVE COMPRESSION OR ISCHEMIA ON CONDUCTION PROPERTIES OF MYELINATED AND NON-MYELINATED NERVE-FIBERS - AN EXPERIMENTAL-STUDY IN THE RABBIT COMMON PERONEAL NERVE
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DOI：
10.1111/j.1748-1716.1989.tb08634.x
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发表时间：
1989-05-01
期刊：
影响因子：
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通讯作者：
ANDERSSON, SA
中科院分区：
文献类型：
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作者：
DAHLIN, LB;SHYU, BC;ANDERSSON, SA
研究了兔腓总神经有髓纤维(A)和无髓纤维(C)在急性、200或400 mmHg梯度压迫2小时期间和之后，或在氮吸入或主动脉阻塞引起的缺血期间的复合动作电位。200毫米汞柱压迫神经约23分钟后阻断A1成分（大髓鞘纤维），而400毫米汞柱压迫将这一时间缩短至11分钟。A2组分（较薄的髓鞘纤维）具有较低的传导速度和较高的抗压性。当神经在200 mmHg下受压2小时时，无髓鞘纤维的传导速度略有下降，而在400 mmHg下受压2小时，c -纤维的振幅和传导速度明显下降。在恢复后的2小时内，A-和c -纤维功能恢复不完全。恢复后2小时有髓纤维变薄。细髓鞘纤维比粗髓鞘纤维对缺氧的反应更敏感，而非髓鞘纤维对缺血诱导的反应不同。结论是非髓鞘纤维具有很强的抗压性，需要非常高的压力（100 ~ 400毫米汞柱）才能影响这些纤维。
Compound action potentials of both myelinated (A) and non-myelinated (C) fibres in the common peroneal nerve of rabbits were studied during and after acute, graded compression of the nerve at 200 or 400 mmHg applied for 2 h or during ischaemia created by nitrogen inhalation or aortic occlusion. Compression of the nerve at 200 mmHg blocked the A1 component (large myelinated fibres) after about 23 min, while compression at 400 mmHg shortened this time to 11 min. The A2 component (thinner myelinated fibres) had a lower conduction velocity and a higher resistance to compression. There was just a slight decrease in conduction velocity of the nonmyelinated fibres when the nerves were compressed at 200 mmHg for 2 h. However, compression at 400 mmHg for 2 h induced a marked deterioration of amplitude and conduction velocity of the C-fibres. There was an incomplete restitution of function of A- and C-fibres during 2 h of recovery. The thinner myelinated fibres during 2 h of recovery. The thinner myelinated fibres were more susceptible to deprivation of oxygen than the thicker ones, while non-myelinated fibres differed in response according to method of ischaemia induction. It is concluded that non-myelinated fibres are very resistant to compression and a very high pressure (> 400 mmHg) is needed to affect these fibres.