Copper-catalyzed three-component carboamination of arynes: expeditious synthesis of o-alkynyl anilines and o-benzoxazolyl anilines
Copper-catalyzed three-component carboamination of arynes: expeditious synthesis of o-alkynyl anilines and o-benzoxazolyl anilines
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铜催化芳烃三组分碳胺化：快速合成邻炔基苯胺和邻苯并恶唑基苯胺
DOI：
10.1021/acs.orglett.9b01427
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Qing Xiao
中科院分区：
文献类型：
--
作者：
Sheng-Li Niu;Jiangtao Hu;Kuicheng He;Ying-Chun Chen;Qing Xiao
发展了一种铜催化的原位生成芳炔、端炔和邻苯甲酰羟胺的三组分反应。通过调节反应条件，可以将反应中的亲核试剂从末端炔扩展到苯并恶唑。这些程序提供了一个模块化的和简便的方法o-炔基苯胺和o-苯并恶唑基苯胺从容易获得的基板，只有一个步骤。
A copper-catalyzed three-component reaction of in situ formed arynes, terminal alkynes, andO-benzoylhydroxylamines has been developed. By adjusting reaction conditions, the nucleophiles in this transformation can be extended from terminal alkynes to benzoxazoles. These procedures provide a modular and facile approach too-alkynyl anilines ando-benzoxazolyl anilines from easily available substrates in only one step.