The Molecular Basis of Voltage-gated Ca2+ Channel Diversity: Is It Time for T?
The Molecular Basis of Voltage-gated Ca2+ Channel Diversity: Is It Time for T?
复制标题
电压门控 Ca2 通道多样性的分子基础：T 时间到了吗？
DOI：
10.1007/s002329900327
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Randall
中科院分区：
文献类型：
--
作者：
A. Randall
抽象的。长期以来，人们就认识到脊椎动物细胞的电压激活 Ca2+ 通道群体存在多样性。最近，从 cDNA 文库中分子克隆相当多的 Ca2+ 通道亚基表明，细胞可以表达的可能 Ca2+ 通道表型的范围可能比以前认识的还要大。近年来的一个挑战是解决重组通道的特性如何与天然细胞中实验表征的对应通道相对应。在这篇简短的评论中，我将概述天然和重组 Ca2+ 通道的特性，然后描述有关它们之间关系的当前协议和争议。
Abstract. The existence of diversity in the voltage activated Ca2+ channel populations of vertebrate cells has been long recognized. More recently, the molecular cloning of a considerable number of Ca2+ channel subunits from cDNA libraries has indicated that the range of possible Ca2+ channel phenotypes a cell can express may be even greater than was previously appreciated. A challenge of recent years has been to resolve how the properties of recombinant channels correspond with their counterparts experimentally characterized in native cells. In this short review I will outline the properties of both native and recombinant Ca2+ channels, and will then describe the current agreements and controversies concerning their relationships to each other.