Cigarette smoking initiation and longitudinal changes in serum lipids and lipoproteins in early adulthood: the Bogalusa Heart Study.
Cigarette smoking initiation and longitudinal changes in serum lipids and lipoproteins in early adulthood: the Bogalusa Heart Study.
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成年早期吸烟开始以及血清脂质和脂蛋白的纵向变化：Bogalusa 心脏研究。
DOI：
10.1093/oxfordjournals.aje.a114379
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发表时间：
1986
影响因子：
5
通讯作者：
Berenson,GS
中科院分区：
文献类型：
--
作者：
Freedman,DS;Srinivasan,SR;Shear,CL;Hunter,SM;Croft,JB;Webber,LS;Berenson,GS
为了研究开始吸烟对生命早期血脂和脂蛋白变化的影响，来自路易斯安那州博加卢萨混血社区的747名9至17岁的不吸烟青少年在初次筛查后5至6年进行了复查。在1981-1983年的复查中，147人报告吸烟(平均持续时间为3.5年；每周吸烟的中位数为20支)。与不吸烟的人相比，开始吸烟的人在随访期间血清甘油三酯和脂蛋白胆固醇水平有更不利的变化，这与女性的年龄、性成熟、肥胖、饮酒和口服避孕药使用无关。开始吸烟与血清总胆固醇水平的升高无关，但与不吸烟者相比，每周吸烟三包或三包以上的白人男性和白人女性的低密度脂蛋白胆固醇平均增加了13.2和11.6 mg/dl，极低密度脂蛋白胆固醇(VLDL-C)增加了5.9和2.4 mg/dl，高密度脂蛋白胆固醇水平增加了15.6和9.2 mg/dl。黑人吸烟者的血清甘油三酯和极低密度脂蛋白胆固醇水平比不吸烟的黑人吸烟者的升高幅度更大。这些发现表明，即使是开始适度吸烟，也可能会产生潜在的长期动脉粥样硬化影响。因此，在生命早期预防吸烟应该是心血管疾病干预的一个重要方面。
To examine the influence of cigarette smoking initiation on serum lipid and lipoprotein changes in early life, 747 nonsmoking 9-to 17-year-olds from the biracial community of Bogalusa, Louisiana were reexamined five to six years following an initial screening. Upon reexamination in 1981–1983, 147 reported smoking cigarettes (mean duration, 3.5 years; median number of weekly cigarettes, 20). Compared with nonsmokers, persons who began smoking had more unfavorable changes in serum triglycerides and lipoprotein cholesterol levels during follow-up, Independently of age, sexual maturation, obesity, alcohol consumption, and oral contraceptive use in females. Smoking initiation was not associated with increases in serum total cholesterol levels, but compared with nonsmokers, white males and white females smoking three or more packs weekly showed additional mean increases of 13.2 and 11.6 mg/dl in low density lipoprotein cholesterol, additional 5.9 and 2.4 mg/dl increases in very low density lipoprotein cholesterol (VLDL-C), and add Wonal decreases of 15.6 and 9.2 mg/dl in high density lipoproteln cholesterol levels, respectively. Black smokers showed larger increases in serum triglycendes and VLDL-C levels than did black non smokers. These findings indicate that the start of even modest cigarette smoking may have potentially long-term atherogenlc effects. Prevention of smoking in early life should therefore be an important aspect of cardiovascular disease intervention.