The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease
The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease
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DOI：
10.1177/1076029616679505
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发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Nsiri, Brahim
中科院分区：
文献类型：
--
作者：
Amara, Ahmed;Mrad, Meriem;Nsiri, Brahim
背景：冠状动脉疾病（CAD），又称动脉粥样硬化性心脏病，是世界范围内死亡率和发病率的主要原因之一。血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性在冠心病病因学中的作用仍有待进一步研究。本研究的目的是确定ACE I/D多态性在冠心病患者中的作用，并研究其与传统危险因素的关联，以评估冠心病的风险。方法：我们的研究人群包括145名突尼斯症状性CAD患者和300名年龄和性别匹配的对照组。所有研究参与者均通过基因组DNA聚合酶链反应扩增获得ACE I/D多态性基因分型。结果：我们的分析显示，ACE D等位基因频率(P < 10(-3)；优势比[OR] = 5.2；95%可信区间[CI] = 3.6-7.6)和DD基因型(P < 10(-3)；Or = 6.8；95% CI = 4.4-10)在冠心病患者中明显比对照组更普遍，可能易患冠心病。我们进一步发现，一些伴随的危险因素（吸烟、糖尿病、高血压、血脂异常和CAD家族史）大大增强了CAD的风险。结论：ACE D等位基因可预测有冠心病风险的个体。进一步研究这些多态性及其与CAD传统危险因素的可能协同作用，有助于更好地预测CAD易感性。
Background: Coronary artery disease (CAD), also known as atherosclerotic heart disease, is a leading cause of mortality and morbidity throughout the world. The role of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene in the etiology of CAD remains to be more completely clarified. The aim of this study was to determine the role of the ACE I/D polymorphism in patients with CAD and to study the association together with traditional risk factors in assessing the risk of CAD.Methods: Our study population included 145 Tunisian patients with symptomatic CAD and a control group of 300 people matched for age and sex. All participants in the study were genotyped for the ACE I/D polymorphisms obtained by polymerase chain reaction amplification on genomic DNA.Results: Our analysis showed that the ACE D allele frequency (P < 10(-3); odds ratio [OR] = 5.2; 95% confidence interval [CI] = 3.6-7.6) and DD genotype (P < 10(-3); OR = 6.8; 95% CI = 4.4-10) are significantly more prevalent among patients with CAD than in controls and may be predisposing to CAD. We further found that the risk of CAD is greatly potentiated by several concomitant risk factors (smoking, diabetes, hypertension, dyslipidemia, and a family history of CAD).Conclusion: The ACE D allele may be predictive in individuals who may be at risk of developing CAD. Further investigations of these polymorphisms and their possible synergisms with traditional risk factors for CAD could help to ascertain better predictability for CAD susceptibility.