Effect of exercise and bisphosphonate on mineral balance and bone density during 360 day antiorthostatic hypokinesia
Effect of exercise and bisphosphonate on mineral balance and bone density during 360 day antiorthostatic hypokinesia
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运动和双磷酸盐对 360 天抗直立性运动功能减退期间矿物质平衡和骨密度的影响
DOI：
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发表时间：
1992
影响因子：
6.2
通讯作者：
L. Buravkova
中科院分区：
文献类型：
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作者：
A. Grigoriev;B. Morukov;V. Oganov;A. Rakhmanov;L. Buravkova
随着我们进入一个涉及长时间飞行的太空探索阶段，有必要使用地面模型来研究防止微重力下骨矿物质流失的对策的长期影响。研究人员对9名卧床休息的受试者进行了360天的矿物质平衡、激素水平和骨密度测量，这些受试者接受了宇航员使用的锻炼计划。其中四名受试者每天服用乙烷- 1 -羟基- 1 -二膦酸盐900毫克，这是一种已知的抑制骨吸收的药物。与120天的对照期相比，双膦酸盐联合运动在前120天减少了50%的负钙平衡，在第二个120天减少了80%，在第三个120天减少了69%。直到第二个120天，当钙平衡改善52%时，单独运动才有效果。负磷平衡不受两种处理的影响。镁平衡在头120天为负，在最后240天恢复到接近正常。联合运动和双膦酸盐治疗在头120天内阻止了血清离子钙的增加和血浆降钙素的减少，以及股骨颈矿物质密度的下降趋势。这些结果表明，在长期模拟微重力下，双膦酸盐可以有效地与运动一起使用，以减少钙的流失，并防止矿物质代谢的一些变化。
As we enter a phase of space exploration that will involve long‐duration flights, there is a need to use ground‐based models to study the long‐term effects of countermeasures to prevent the loss of bone mineral in microgravity. Mineral balances, hormone levels, and bone density were measured for 360 days in nine bed rest subjects treated with an exercise program used by cosmonauts. Four of these subjects received the bisphosphonate, ethane‐1‐hydroxy‐1‐disphosphonate, 900 mg daily, a drug known to inhibit bone resorption. Compared to a 120 day control period, the bisphosphonate combined with exercise reduced negative calcium balances by 50% for the first 120 days, 80% for the second 120 days, and 69% during the third 120 days. Exercise alone had no effect until the second 120 day period, when calcium balance improved 52%. Negative phosphorus balances were not affected by either treatment. Magnesium balances were negative during the first 120 days and returned to nearly normal during the last 240 days in both groups. The combined exercise and bisphosphonate treatment prevented increases in serum ionized calcium and decreases in plasma calcitonin during the first 120 days, as well as trends toward decreases in the mineral density of the femoral neck. These results suggest that bisphosphonates can be efficiently used together with exercise to reduce calcium loss and prevent some of the changes in mineral metabolism during long‐term simulated microgravity.
影响因子：
158.5
作者：
STEWART, AF;ADLER, M;BROADUS, AE
通讯作者：
BROADUS, AE