Effect of early propranolol treatment in an animal model of congestive cardiomyopathy: I Mortality and Ca2+ transport in sarcoplasmic reticulum.
Effect of early propranolol treatment in an animal model of congestive cardiomyopathy: I Mortality and Ca2+ transport in sarcoplasmic reticulum.
复制标题
早期普萘洛尔治疗对充血性心肌病动物模型的影响：死亡率和肌浆网中的 Ca2+ 转运。
DOI：
10.1093/cvr/18.6.371
复制
发表时间：
1984
影响因子：
10.8
通讯作者：
T. Rublein
中科院分区：
文献类型：
--
作者：
N. Staley;G. Noren;S. Einzig;T. Rublein
年轻的火鸡近交充血性心肌病治疗心得安之前的发展，心脏扩大。一日龄的近交系和商业火鸡接受普萘洛尔，2 mg X kg-1 X day-1，持续1个月。普萘洛尔治疗的近交系鸟类显示出显着降低死亡率从5日龄至15日龄时，与未经处理的近交系鸟类。然而，到28日龄时，处理的近交系鸟类的累积死亡率与未处理的近交系鸟类相同，分别为29%和32%。普萘洛尔处理和未处理的商业鸟类的28天累积死亡率为5%。在离体心肌肌浆网钙转运研究在10日龄和28日龄。在10日龄的钙摄取和钙结合在普萘洛尔处理的鸟类，分别减少到56%和83%，在未处理的近交系鸟类的值。到28日龄，处理和未处理的近交系鸟类的钙吸收和钙结合是相似的。Ca 2+刺激的ATP酶活性显着升高，在处理的近交系鸟类相比，年龄匹配的未处理的近交系鸟类在10日龄和28日龄。在10或28日龄时，普萘洛尔处理的商业对照鸟的离体心脏SR中的Ca 2+转运与未处理的商业鸟的值没有显著差异。早期死亡率的改善可能是由于心律失常的预防。普萘洛尔通过解偶联Ca ~（2+）刺激的ATP酶改变离体鸡心肌SR的Ca ~（2+）转运。这是由于普萘洛尔对SR膜的直接作用还是由于其β-肾上腺素能阻滞作用而发生尚不清楚。
Young turkeys inbred for congestive cardiomyopathy were treated with propranolol prior to the development of cardiac enlargement. One-day-old inbred and commercial turkeys received propranolol, 2 mg X kg-1 X day-1 for 1 month. Propranolol treated inbred birds showed a significantly reduced mortality from 5 to 15 days of age when compared with untreated inbred birds. However, by 28 days of age, cumulative mortality in the treated inbred birds was equal to that in the untreated inbred birds, 29 and 32%, respectively. Propranolol-treated and untreated commercial birds have a 28-day cumulative mortality of 5%. Ca2+ transport in isolated cardiac sarcoplasmic reticulum was studied at 10 and 28 days of age. At 10 days of age Ca2+ uptake and Ca2+ binding in propranolol-treated birds was reduced to 56% and 83%, respectively, of values in untreated inbred birds. By 28 days of age Ca2+ uptake and Ca2+ binding in treated and untreated inbred birds were similar. Ca2+-stimulated ATPase activity was significantly elevated in treated inbred birds compared with age-matched untreated inbred birds at 10 and 28 days of age. Ca2+ transport in isolated cardiac SR from propranolol-treated commercial control birds was not significantly different from the values in untreated commercial birds at 10 or 28 days of age. Improvement in early mortality may be due to the prevention of arrhythmias. Propranolol alters Ca2+ transport in isolated cardiac SR from inbred birds by uncoupling Ca2+-stimulated ATPase. Whether this is due to a direct effect of propranolol on the SR membrane or occurs from its beta-adrenergic blocking action is unclear.