CRC screening, past, present, and future: a tribute to Emmet Keeffe.
CRC screening, past, present, and future: a tribute to Emmet Keeffe.
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CRC 筛查，过去、现在和未来：向 Emmet Keeffe 致敬。
DOI：
10.1007/s10620-015-3603-2
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发表时间：
2015
影响因子：
3.1
通讯作者：
Kaunitz,JonathanD
中科院分区：
文献类型：
--
作者：
Ahnen,DennisJ;Bresalier,RobertS;Levin,Bernard;Kaunitz,JonathanD
过去几十年来，癌症生存率取得了惊人的进步，代表了现代医学的胜利。结直肠癌 (CRC) 是全球最常见的三种癌症之一，它也不例外，从 20 世纪 70 年代之前起，经济发达国家的发病率不断下降，生存率不断提高，在美国最为明显 [1]。对于我们这个行业来说，结直肠癌的令人兴奋和独特的故事是，这些下降很大程度上可以归因于胃肠病学家和相关专家进行的干预措施，特别是自 20 世纪 90 年代以来，当时筛查结肠镜检查首次受到关注。这种筛查方式的广泛采用代表着预防医学的胜利和我们职业的福音。当然，这是有代价的，因为结肠镜检查，至少在美国的实施方式，是昂贵、耗时的，而且至少在准备过程中是不舒服的。因此，对新的基于粪便和血液的 CRC 筛查测试的探索非常激烈，正如特刊后面所述，人们渴望了解 CRC 病理生理学。 作为主编 (JDK)，我非常高兴地介绍这期《消化疾病与科学》特刊，该特刊由两位世界知名的该领域专家 Dennis Ahnen 和 Bob Bresalier 编辑。我相信本期是 CRC 筛查文献中的一个高峰，代表了有史以来对该主题最全面、最详细的报道。由于撰稿人拥有丰富的专业知识、知识和经验，每篇评论的质量和专业知识都是一流的，这是对编辑们的致敬。因此，本期特刊将为任何渴望获得有关 CRC 筛查、流行病学、分子发病机制、特殊筛查人群治疗和模式以及更多主题的最准确和详细信息的学者提供长期参考。
The stunning improvements in cancer survival over the past few decades represent triumphs of modern medicine. Colorectal cancer (CRC), which is included in the top three most prevalent cancers worldwide, is no exception, with declining incidence and improved survival extending from before the 1970s in economically developed countries, most pronounced in the USA [1]. The exciting and unique story with CRC for our profession is that much of these declines can be attributed to the interventions conducted by gastroenterologists and related specialists particularly since the 1990s, when screening colonoscopy first gained traction. The widespread adoption of this screening modality represents a victory for preventative medicine and a boon for our profession. This, of course comes at a price, since colonoscopy, at least the way it is practiced in the USA, is a costly, time-consuming, and—at least in its preparation—uncomfortable. Therefore, the search for new stool-and blood-based CRC screening tests is intense, as is desire to understand CRC pathophysiology, as described later in the Special Issue.As Editor-in-Chief (JDK), it is my distinct pleasure to introduce this Special Issue of Digestive Diseases and Sciences, edited by two consummate, world-renowned experts in the field, Dennis Ahnen and Bob Bresalier. I believe this issue is a high point in the CRC screening literature, representing the most comprehensive and detailed coverage of the topic ever compiled. It is a tribute to the editors that the quality and expertise of each review is in the first rank, due to the considerable expertise, knowledge, and experience of the contributing authors. As such, this Special Issue will serve as a longstanding reference for any scholar desirous of the most accurate and detailed information regarding any aspect of CRC screening, for epidemiology, molecular pathogenesis, treatment of special screening populations and modalities, and many more topics.