Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein.
Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein.
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DOI：
10.4331/wjbc.v1.i11.327
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发表时间：
2010-11-26
期刊：
影响因子：
--
通讯作者：
Okajima, Fumikazu
中科院分区：
文献类型：
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作者：
Sato, Koichi;Okajima, Fumikazu
高密度脂蛋白（HDL）介导的反向胆固醇转运是维持体内胆固醇的重要机制，因此，脂蛋白具有重要的抗动脉粥样硬化作用。然而，最近的研究表明，HDL 具有多种抗炎和抗动脉粥样硬化作用，与胆固醇代谢无关。本综述概述了 1-磷酸鞘氨醇 (S1P)/S1P 受体和载脂蛋白 A-I/B 类清道夫受体 I 型系统在抗动脉粥样硬化 HDL 作用中的作用。此外，还讨论了HDL颗粒中S1P存在的生理意义。
The reverse cholesterol transport mediated by high-density lipoprotein (HDL) is an important mechanism for maintaining body cholesterol, and hence, the crucial anti-atherogenic action of the lipoprotein. Recent studies, however, have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism. The present review provides an overview of the roles of sphingosine 1-phosphate (S1P)/S1P receptor and apolipoprotein A-I/scavenger receptor class B type I systems in the anti-atherogenic HDL actions. In addition, the physiological significance of the existence of S1P in the HDL particles is discussed.