Specialized Intercellular Communications via Cytonemes and Nanotubes.
Specialized Intercellular Communications via Cytonemes and Nanotubes.
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DOI：
10.1146/annurev-cellbio-100617-062932
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发表时间：
2018-10-06
影响因子：
11.3
通讯作者：
Buszczak M
中科院分区：
文献类型：
--
作者：
Yamashita YM;Inaba M;Buszczak M
近年来，薄膜突起，如细胞丝和隧道纳米管已成为一种新的机制，细胞间的通讯。基于突起的细胞相互作用允许参与细胞之间的特定通信，并且与基于分泌-扩散的细胞间通信相比具有明显的优势。在不同的系统中识别出基于信号传导的信号表明，这种机制是许多细胞类型所采用的普遍存在和普遍的通信手段。此外，越来越多的证据表明，基于免疫的细胞间通讯通常参与包括癌症和感染在内的发病机制。在这里，我们回顾了我们目前的理解，基于脑电的细胞间通信。
In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes have emerged as a novel mechanism of intercellular communications. Protrusion-based cellular interactions allow specific communication between participating cells, and would have a distinct spectrum of advantages compared to secretion-diffusion-based intercellular communications. Identification of protrusion-based signaling in diverse systems suggests that this mechanism is a ubiquitous and prevailing means of communication employed by many cell types. Moreover, accumulating evidence indicates that protrusion-based intercellular communications are often involved in pathogenesis including cancers and infections. Here we review our current understanding of protrusion-based intercellular communications.
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作者：
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通讯作者：
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Brown, Elizabeth
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