Review of bats and SARS.
Review of bats and SARS.
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DOI：
10.3201/eid1212.060401
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发表时间：
2006-12
影响因子：
11.8
通讯作者：
Eaton BT
中科院分区：
文献类型：
--
作者：
Wang LF;Shi Z;Zhang S;Field H;Daszak P;Eaton BT
TOC总结：在马蹄蝙蝠中发现SARS样冠状病毒，凸显了未来由蝙蝠来源的不同冠状病毒引起疫情的可能性。蝙蝠已被确定为越来越多的新出现的人畜共患病毒的天然宿主，包括亨尼帕病毒和狂犬病病毒的变体。最近，我们和另一个小组独立地确定了几种菊头蝠属物种（菊头蝠属）作为大量病毒的储存宿主，这些病毒与严重急性呼吸系统综合征（SARS）相关的冠状病毒有密切的遗传关系。我们目前的研究重点是确定在2002-2003年和2003-2004年爆发的SARS冠状病毒的祖病毒的水库物种。除了SARS样冠状病毒外，许多其他新的蝙蝠冠状病毒，属于现有的3种冠状病毒组中的第1组和第2组，已经通过PCR检测到。蝙蝠类SARS冠状病毒的发现，以及冠状病毒在蝙蝠体内的巨大遗传多样性，为SARS冠状病毒的起源和传播提供了新的线索。
TOC Summary: The discovery of SARS-like coronaviruses in horseshoe bats highlights the possibility of future outbreaks caused by different coronaviruses of bat origin. Bats have been identified as a natural reservoir for an increasing number of emerging zoonotic viruses, including henipaviruses and variants of rabies viruses. Recently, we and another group independently identified several horseshoe bat species (genus Rhinolophus) as the reservoir host for a large number of viruses that have a close genetic relationship with the coronavirus associated with severe acute respiratory syndrome (SARS). Our current research focused on the identification of the reservoir species for the progenitor virus of the SARS coronaviruses responsible for outbreaks during 2002–2003 and 2003–2004. In addition to SARS-like coronaviruses, many other novel bat coronaviruses, which belong to groups 1 and 2 of the 3 existing coronavirus groups, have been detected by PCR. The discovery of bat SARS-like coronaviruses and the great genetic diversity of coronaviruses in bats have shed new light on the origin and transmission of SARS coronaviruses.