Minor Valepotriates from Valeriana jatamansi and Their Cytotoxicity against Metastatic Prostate Cancer Cells
Minor Valepotriates from Valeriana jatamansi and Their Cytotoxicity against Metastatic Prostate Cancer Cells
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DOI：
10.1055/s-0034-1383369
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发表时间：
2015-01-01
期刊：
影响因子：
2.7
通讯作者：
Zhang, Wei-Dong
中科院分区：
文献类型：
--
作者：
Lin, Sheng;Fu, Peng;Zhang, Wei-Dong
从蜘蛛香（Valeriana jatamansi）全草中分离得到10个新的缬草三酯化合物，即蜘蛛香缬草素P-Y（1-10）和1个已知化合物甘松素（nardostachin，11）。新化合物的结构通过详细的光谱数据分析确定。评价了分离的化合物对PC-3 M细胞的细胞毒活性，并检查了从日本血吸虫中分离的所有戊酸三酯的结构-活性关系。结果表明，戊三酸酯中的C-3-C-4双键、环氧乙烷环和10-氯原子具有重要的构效关系。
Ten new valepotriates, jatamanvaltrates P-Y (1-10) and a known one, nardostachin (11), have been isolated from the whole plants of Valeriana jatamansi. The structures of the new compounds were determined by detailed spectroscopic data analysis. The isolated compounds were evaluated for cytotoxic activity against PC-3M cells, and a structure-activity relationship was examined for all the valepotriates isolated from V. jatamansi. The results highlighted the structure-activity relationship importance of the C-3-C-4 double bond, the oxirane ring, and the 10-chlorine in the valepotriates.