Predicting the growth of nanoscale nuclei by histotripsy pulses.
Predicting the growth of nanoscale nuclei by histotripsy pulses.
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DOI：
10.1088/0031-9155/61/7/2947
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发表时间：
2016-04-07
影响因子：
3.5
通讯作者：
Holland CK
中科院分区：
文献类型：
--
作者：
Bader KB;Holland CK
组织解剖术是一种聚焦超声疗法，通过空化的机械作用消融组织。组织解剖引发的空化活动是由从附带核散射的冲击超声脉冲（冲击散射组织解剖）或纯粹的拉伸超声脉冲（显微解剖）产生的。对 Yang/Church 模型进行数值积分，以预测暴露于测量的冲击散射组织解剖脉冲的空化核的行为。气泡运动表现出仅膨胀行为，表明组织解剖脉冲的消融作用与气泡的最大尺寸相关。 Holland 和 Apfel 的分析模型被扩展以预测冲击散射组织解剖和显微解剖激发的空化核的最大尺寸。对于完全发展的冲击散射组织解剖脉冲（>72 MPa 峰值正压），分析模型和数值模型的预测一致在 2% 以内。对于未完全发展的冲击散射组织解剖脉冲 (<72 MPa)，分析模型低估了最大尺寸不到 5%。该分析模型还用于预测显微声波成核的气泡生长，并且发现与实验观察结果一致。基于扩展的分析模型，开发了一些指标来根据组织解剖脉冲预测治疗区域的范围。
Histotripsy is a focused ultrasound therapy that ablates tissue through the mechanical action of cavitation. Histotripsy-initiated cavitation activity is generated from shocked ultrasound pulses that scatter from incidental nuclei (shock scattering histotripsy), or purely tensile ultrasound pulses (microtripsy). The Yang/Church model was numerically integrated to predict the behavior of the cavitation nuclei exposed to measured shock scattering histotripsy pulses. The bubble motion exhibited expansion only behavior, suggesting that the ablative action of a histotripsy pulse is related to the maximum size of the bubble. The analytic model of Holland and Apfel was extended to predict the maximum size of cavitation nuclei for both shock scattering histotripsy and microtripsy excitations. The predictions of the analytic model and the numerical model agree within 2% for fully developed shock scattering histotripsy pulses (>72 MPa peak positive pressure). For shock scattering histotripsy pulses that are not fully developed (<72 MPa), the analytic model underestimated the maximum size by less than 5%. The analytic model was also used to predict bubble growth nucleated from microtripsy insonations, and was found to be consistent with experimental observations. Based on the extended analytic model, metrics were developed to predict the extent of the treatment zone from histotripsy pulses.