A concise stereoselective total synthesis of (+)-artemisinin
A concise stereoselective total synthesis of (+)-artemisinin
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DOI：
10.1016/j.tet.2010.01.051
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发表时间：
2010-03-13
期刊：
影响因子：
2.1
通讯作者：
Srihari, P.
中科院分区：
文献类型：
--
作者：
Yadav, J. S.;Thirupathaiah, B.;Srihari, P.
本文描述了从现成的(R)-(+)-香茅醛开始的无保护基团、简洁和立体选择性的(+)-青蒿素的全合成。不对称1,4加成、醛醇缩合、烯反应、区域选择性硼氢化反应是目标分子全合成的关键步骤。(C) 2010 Elsevier Ltd.版权所有。
A protective group free, concise, and stereoselective total synthesis of (+)-artemisinin, starting from readily available (R)-(+)-citronellal, is described. Asymmetric 1, 4-addition, Aldol condensation, Ene reaction, regioselective hydroboration are the key steps involved in the total synthesis of the target molecule. (C) 2010 Elsevier Ltd. All rights reserved.