Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa.
Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa.
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DOI：
10.1016/j.bmcl.2013.03.038
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发表时间：
2013-05
影响因子：
2.7
通讯作者：
Ai-hong Liu;Ding-Quan Liu;Tongjun Liang;Xiao-Qing Yu;Mei-Tang Feng;Li-gong Yao;Yi Fang;Bin Wang-
中科院分区：
文献类型：
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作者：
Ai-hong Liu;Ding-Quan Liu;Tongjun Liang;Xiao-Qing Yu;Mei-Tang Feng;Li-gong Yao;Yi Fang;Bin Wang-
Two new prenylated para-xylenes, named caulerprenylols A (1) and B (2), were isolated from the green alga Caulerpa racemosa, collected from the Zhanjiang coastline, China. The structures of the two metabolites were elucidated on the basis of detailed spectroscopic analysis. This is the first report of prenylated para-xylenes from marine algae and from marine organisms as well. Moreover, caulerprenylol B (2) is also characterized by an uncommon indane ring system. In in vitro bioassays, the new compounds exhibited a broad spectrum of antifungal activity against Candida glabrata (537), Trichophyton rubrum (Cmccftla), and Cryptococcus neoformans (32609) with MIC80values between 4 and 64μg/mL when compared to amphotericin B (MIC80values of 2.0, 1.0, and 4.0μg/mL, respectively) as a positive control and showed no growth inhibition activity against the tumor cells HL60 and A549.
