Dihydropyrrolizine derivatives from unsaturated pyrrolizidine alkaloids.
Dihydropyrrolizine derivatives from unsaturated pyrrolizidine alkaloids.
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不饱和吡咯里西啶生物碱的二氢吡咯里西嗪衍生物。
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
A. Mattocks
中科院分区：
文献类型：
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作者：
A. Mattocks
描述了将具有脱氢吡咯里西啶环的生物碱及其N-氧化物转化为二氢吡咯里嗪衍生物的方法，当将生物碱给予动物时，二氢吡咯里嗪衍生物也作为代谢物形成。描述了这些产品的一些特性。它们的行为类似于吡咯衍生物，而酯类衍生物是高反应性烷基化剂，这可能是生物碱毒性作用的原因。
Methods are described for converting alkaloids having the dehydropyrrolizidine ring, and their N-oxides, to dihydropyrrolizine derivatives, which are also formed as metabolites when the alkaloids are administered to animals. Some properties of these products are described. They behave as pyrrole derivatives, and those which are esters are highly reactive alkyiating agents, which are probably responsible for toxic effects of the alkaloids.