A Mechanobiological Model for Tissue Differentiation that Includes Angiogenesis: A Lattice-Based Modeling Approach
A Mechanobiological Model for Tissue Differentiation that Includes Angiogenesis: A Lattice-Based Modeling Approach
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DOI：
10.1007/s10439-008-9594-9
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发表时间：
2009-01-01
影响因子：
3.8
通讯作者：
Prendergast, Patrick J.
中科院分区：
文献类型：
--
作者：
Checa, Sara;Prendergast, Patrick J.
机械生物学模型先前已被用于预测组织分化过程的时间过程，局部机械环境作为细胞活性的调节器。然而，由于向细胞供应氧气和营养物质也是细胞分化的调节剂，并且氧气扩散仅限于毛细血管的几百微米，因此新血管网络的形态也可能在该过程中发挥关键作用。本文提出了一种基于局部力学环境和局部血管分布的组织分化计算模型。规则的晶格用于模拟细胞活动（迁移、增殖、分化、凋亡和血管生成）。毛细血管网络形成的算法包括血管生长的机械调节。模拟剪切下骨/植入物间隙中的组织分化。该模型预测的毛细血管网络中发现的实验研究和异质模式的组织分化，这是由毛细血管网络的形态的影响。较高的机械负荷导致血管发育较慢，骨组织形成延迟。
Mechanobiological models have previously been used to predict the time course of the tissue differentiation process, with the local mechanical environment as the regulator of cell activity. However, since the supply of oxygen and nutrients to cells is also a regulator of cell differentiation and oxygen diffusion is limited to few hundred micrometers from capillaries, the morphology of the new vascular network may also play a critical role in the process. In this paper, a computational model for tissue differentiation based on the local mechanical environment and the local vascularity is presented. A regular lattice is used to simulate cell activity (migration, proliferation, differentiation, apoptosis, and angiogenesis). The algorithm for capillary network formation includes mechanoregulation of vessel growth. A simulation of tissue differentiation in a bone/implant gap under shear was performed. The model predicts capillary networks similar to those found in experimental studies and heterogeneous patterns of tissue differentiation, which are influenced by the morphology of the capillary network. Higher mechanical loads caused slower vascular development and delayed bone tissue formations.