Early childhood risk factors for constipation and soiling at school age: an observational cohort study.
Early childhood risk factors for constipation and soiling at school age: an observational cohort study.
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DOI：
10.1136/bmjpo-2017-000230
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发表时间：
2018
影响因子：
2.6
通讯作者：
Joinson C
中科院分区：
文献类型：
--
作者：
Heron J;Grzeda M;Tappin D;von Gontard A;Joinson C
便秘和脏污在儿童时期很常见。这项研究调查了儿童便秘和污垢的共病以及儿童早期这些问题的危险因素。样本包括8,435名来自雅芳纵向研究的父母和孩子，他们的母亲报告了便秘(6个时间点，介于4至10 年)和脏污(5个时间点，介于4至9 年)。我们使用潜在类分析来提取便秘和污垢的纵向模式。我们使用多项Logistic回归模型检验了潜伏期与母亲报告的幼儿早期危险因素(大便一致性、母乳喂养、社会经济背景、妊娠、出生体重、发育水平和开始如厕训练的年龄)是否存在差异关联。我们提取了四个潜在的类别：“正常”(74.5%：便秘或污垢的概率非常低)、“单独便秘”(13.2%)、“单独污浊”(7.5%)和“便秘伴污垢”(4.8%)。两岁半时排硬便与便秘几率增加有关。18个月的发育迟缓与单独弄脏和便秘与弄脏有关，但不只是便秘。我们发现与社会经济背景有关联的证据有限，没有证据表明与开始如厕训练、母乳喂养、胎龄或出生体重有关的年龄。便秘本身就是这个队列中最常见的模式。需要对儿童早期硬便进行治疗，以防止学龄期的慢性便秘。有污物的便秘比单独污物更少见。需要进一步研究非固持性污垢的原因。
Constipation and soiling are common in childhood. This study examines the comorbidity between childhood constipation and soiling and early childhood risk factors for these problems. The sample comprised 8435 participants from the Avon Longitudinal Study of Parents and Children with maternally reported measures of constipation (six time points between 4 and 10 years) and soiling (five time points between 4 and 9 years). We used latent class analysis to extract longitudinal patterns of constipation and soiling. We examined whether the latent classes are differentially associated with maternally reported risk factors in early childhood (stool consistency, breast feeding, socioeconomic background, gestation, birth weight, developmental level and age at initiation of toilet training) using multinomial logistic regression models. We extracted four latent classes: ‘normative’ (74.5%: very low probability of constipation or soiling), ‘constipation alone’ (13.2%), ‘soiling alone’ (7.5%) and ‘constipation with soiling’ (4.8%). Hard stools at 2½ years were associated with increased odds of constipation alone. Developmental delay at 18 months was associated soiling alone and constipation with soiling, but not constipation alone. We found limited evidence of associations with socioeconomic background and no evidence of associations with age at initiation of toilet training, breast feeding, gestational age or birth weight. Constipation alone was the most prevalent pattern in this cohort. Treatment for hard stools in early childhood is needed to prevent chronic constipation at school age. Constipation with soiling was less common than soiling alone. Further research is needed into the causes of non-retentive soiling.
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DOI：
10.5223/pghn.2017.20.1.1
发表时间：
2017-03
期刊：
Pediatric gastroenterology, hepatology & nutrition
影响因子：
--
作者：
Zeevenhooven J;Koppen IJ;Benninga MA
通讯作者：
Benninga MA
影响因子：
2.1
作者：
Chung, Jae Min;Lee, Sang Don;Han, Sang Won
通讯作者：
Han, Sang Won
DOI：
10.1097/01.mpg.0000149964.77418.27
发表时间：
2005-03-01
影响因子：
2.9
作者：
van der Wal, MF;Benninga, MA;Hirasing, RA
通讯作者：
Hirasing, RA
带有协变量的潜在类建模： 两种改进的三步法
影响因子：
5.4
作者：
Vermunt, Jeroen K.
通讯作者：
Vermunt, Jeroen K.
DOI：
10.1097/mpg.0b013e3181d33b7d
发表时间：
2010-10-01
影响因子：
2.9
作者：
Rajindrajith, Shaman;Devanarayana, Niranga Manjuri;Benninga, Marc A.
通讯作者：
Benninga, Marc A.