Sulfated polysaccharides from pacific abalone reduce diet-induced obesity by modulating the gut microbiota
Sulfated polysaccharides from pacific abalone reduce diet-induced obesity by modulating the gut microbiota
复制标题
来自太平洋鲍鱼的硫酸化多糖通过调节肠道微生物群来减少饮食引起的肥胖
DOI：
10.1016/j.jff.2018.05.061
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发表时间：
2018-08-01
影响因子：
5.6
通讯作者：
Song, Shuang
中科院分区：
文献类型：
--
作者：
Ai, Chunqing;Duan, Mengmeng;Song, Shuang
Sulfated polysaccharides from abalone (Haliotis discus hannai Ino) gonad (AGSP) is shown to have various bioactivities, but it remains unknown whether AGSP produces any effect on high fat diet (HFD)-induced obesity. This study indicated that AGSP inhibited weight gain and improved body composition in HFD-fed mice without reducing food consumption. Moreover, AGSP reduced fat accumulation in the liver and epididymal fat tissues of HFD-fed mice via the modulation of lipid metabolism. Such effects could be associated with the improvement of the gut microbiota as indicated by a decreased ratio of Firmicutes/Bacteroidetes and overall structure changes of the gut microbiota. Butyrate as the end product of bacterial fermentation was significantly increased in AGSP-fed mice, and thus may inhibit lipid-related gene expressions via G protein-coupled receptors-dependent pathways. In short, it suggested that AGSP can be used as beneficial polysaccharides to improve obesity and its associated disorders.
