Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta
Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta
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DOI：
10.1017/s0031182010000028
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发表时间：
2010-07-01
期刊：
影响因子：
2.4
通讯作者：
Stear, M. J.
中科院分区：
文献类型：
--
作者：
Murphy, L.;Eckersall, P. D.;Stear, M. J.
伊加和IgE的活性对Teladorsagia circumcincta进行了研究，在一群特克塞尔羔羊自然，混合线虫感染羔羊。伊加活性的分布类似于γ分布，而IgE活性不同。Box-Cox分析表明，X-0.25是使IgE应答正常化的合适转换。转化的IgE活性受到中等至强的遗传控制。通过蛋白质组学分析鉴定了9种不同的过敏原。选择原肌球蛋白进行进一步分析。IgE活性;对原肌球蛋白的抑制是中度可遗传的，并与取样时卵数减少和体重减轻有关。
IgA and IgE activity against Teladorsagia circumcincta was investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs. The distribution of IgA activity was similar to a gamma distribution whereas IgE activity was different. Box-Cox analysis demonstrated that X-0.25 was a suitable transformation to normalise IgE responses. The transformed IgE activity was under moderate to strong genetic control. Nine different allergens were identified by proteomic analysis. Tropomyosin was selected for further analysis. IgE activity;against tropomyosin was moderately heritable and associated with decreased egg counts and with reduced body weight at the time of sampling.