Phylogenetic analysis of highly pathogenic avian influenza A(H5N8) virus outbreak strains provides evidence for four separate introductions and one between-poultry farm transmission in the Netherlands, November 2014
Phylogenetic analysis of highly pathogenic avian influenza A(H5N8) virus outbreak strains provides evidence for four separate introductions and one between-poultry farm transmission in the Netherlands, November 2014
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DOI：
10.2807/1560-7917.es2015.20.26.21174
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发表时间：
2015-07-02
期刊：
影响因子：
19
通讯作者：
Bossers, A.
中科院分区：
文献类型：
--
作者：
Bouwstra, R. J.;Koch, G.;Bossers, A.
对2014年在荷兰家禽养殖场引起疫情的高致病性甲型禽流感（H5 N8）病毒株进行的系统发育分析提供了证据，证明该病毒在相距16-112公里的农场的四次疫情中分别引入，以及在第三次和第四次疫情之间的农场间传播。农场相距550 m。此外，分析显示，所有欧洲和两种日本H5 N8病毒株都非常密切相关，似乎起源于2014年7月至9月之间出现的计算共同祖先。我们的研究结果表明，荷兰爆发的病毒株“Ter Aar”和2014年德国首次爆发的病毒株有着共同的祖先。此外，数据表明，荷兰爆发的病毒起源于2009年左右在亚洲（可能是中国）流行的H5 N8病毒，随后传播到韩国和日本，最后也传播到欧洲。该病毒的演变似乎在日本和欧洲遵循一条平行的轨迹，这支持了H5 N8病毒在西伯利亚繁殖地的迁徙野生水禽之间交换并从那里由迁徙水禽携带到欧洲的假设。
Phylogenetic analysis of highly pathogenic avian influenza A(H5N8) virus strains causing outbreaks in Dutch poultry farms in 2014 provides evidence for separate introduction of the virus in four outbreaks in farms located 16-112 km from each other and for between-farm transmission between the third and fourth outbreak in farms located 550 m from each other. In addition, the analysis showed that all European and two Japanese H5N8 virus strains are very closely related and seem to originate from a calculated common ancestor, which arose between July and September 2014. Our findings suggest that the Dutch outbreak virus strain 'Ter Aar' and the first German outbreak strain from 2014 shared a common ancestor. In addition, the data indicate that the Dutch outbreak viruses descended from an H5N8 virus that circulated around 2009 in Asia, possibly China, and subsequently spread to South Korea and Japan and finally also to Europe. Evolution of the virus seemed to follow a parallel track in Japan and Europe, which supports the hypothesis that H5N8 virus was exchanged between migratory wild waterfowl at their breeding grounds in Siberia and from there was carried by migrating waterfowl to Europe.