Endogenous nitric oxide in allergic airway disease.

Endogenous nitric oxide in allergic airway disease.
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过敏性气道疾病中的内源性一氧化氮。

DOI:
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发表时间:
2000
影响因子:
14.2
通讯作者:
Robert G. Townley
Robert G. Townley
中科院分区:
医学1区
文献类型:
--
作者:
P. Silkoff;Richard A. Robbins;Benjamin Gaston;Jon O. Lundberg;Robert G. Townley

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一氧化氮(NO)在生理和病理机制中的作用已得到深入研究。呼出气中NO的存在和鼻气道中的高浓度刺激了许多研究,将呼出气和鼻NO作为气道炎症的潜在标志物进行检查,从而能够重复监测侵入性检查(例如支气管镜检查)无法实现的气道炎症。在气道炎症中,NO不仅是一种标志物,而且可能具有抗炎和促炎作用。鼻内NO测定可用于鼻部疾病的无创性诊断和监测。这篇综述是由1999年在美国过敏、哮喘和免疫学学会年会上发表关于一氧化氮的演讲的演讲者编写的,演讲内容涉及呼出和鼻内一氧化氮、一氧化氮的体外研究、气道一氧化氮形成的化学过程以及呼出介质的标准化测量。
There has been intense research into the role nitric oxide (NO) plays in physiologic and pathologic mechanisms. The presence of NO in exhaled breath and the high concentrations in nasal airways stimulated many studies examining exhaled and nasal NO as potential markers of airway inflammation, enabling repeated monitoring of airway inflammation not possible with invasive tests (eg, bronchoscopy). In airway inflammation, NO is not merely a marker but may have anti-inflammatory and proinflammatory effects. Nasal NO measurement may be used in the noninvasive diagnosis and monitoring of nasal disease. This review was compiled by speakers who gave presentations on NO at the annual meeting of the American Academy of Allergy, Asthma, and Immunology in 1999 on exhaled and nasal NO, in vitro studies of NO, the chemistry of airway NO formation, and standardized measurement of exhaled mediators.
DOI: 10.1126/science.284.5414.651
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