Lowered performance in working memory and attentional sub-processes are most prominent in multi-domain amnestic mild cognitive impairment subtypes
Lowered performance in working memory and attentional sub-processes are most prominent in multi-domain amnestic mild cognitive impairment subtypes
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DOI：
10.1111/psyg.12042
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发表时间：
2014-03-01
期刊：
影响因子：
2
通讯作者：
Summers, Mathew J.
中科院分区：
文献类型：
--
作者：
Klekociuk, Shannon Z.;Summers, Mathew J.
背景研究表明，工作记忆和注意力缺陷可能存在于轻度认知障碍（MCI）中。然而，修订后的 MCI 亚型中这些域的功能状态仍不清楚，特别是因为之前的研究已经使用与 MCI 亚型分类相同的测试来检查这些认知域。本研究的目的是通过一系列神经心理学测试来检查 MCI 亚型的工作记忆和注意力功能，这些测试与用于分类 MCI 亚型的测试不同。方法总共 122 名 60-90 岁的成年人在基线时被分为遗忘型 MCI、非遗忘型 MCI 和多域遗忘型 (a-MCI+)。使用一系列与筛选时用于对 MCI 进行分类的测试不同的测试来检查参与者的注意力和工作记忆能力。结果 a-MCI+ 组在所有工作记忆任务和特定的注意力子过程中表现最差。非遗忘 MCI 组仅在视觉广度和复杂持续注意力方面表现较低。没有证据表明遗忘性 MCI 参与者的注意力或工作记忆受损。 结论 当使用不同于分类时使用的措施对 MCI 队列进行评估时，a-MCI+ 受试者的工作记忆和注意力功能受损最严重。这些结果支持了之前的研究结果，即 a-MCI+ 更类似于早期阿尔茨海默病，并且与其他 MCI 亚型的患者相比，a-MCI+ 患者未来认知能力下降的速度可能更快。
BackgroundResearch suggests that working memory and attention deficits may be present in mild cognitive impairment (MCI). However, the functional status of these domains within revised MCI subtypes remains unclear, particularly because previous studies have examined these cognitive domains with the same tests that were used to classify MCI subtypes. The aim of this study was to examine working memory and attention function in MCI subtypes on a battery of neuropsychological tests that were distinct from those used to classify MCI subtypesMethodsA total of 122 adults aged 60-90 years were classified at baseline as amnestic MCI, non-amnestic MCI, and multi-domain amnestic (a-MCI+). The attentional and working memory capacity of participants was examined using a battery of tests distinct from those used to classify MCI at screening.ResultsThe a-MCI+ group demonstrated the poorest performance on all working memory tasks and specific sub-processes of attention. The non-amnestic MCI group had lowered performance on visual span and complex sustained attention only. There was no evidence of either attentional or working memory impairment in the amnestic MCI participants.ConclusionWhen MCI cohorts are assessed on measures distinct from those used at classification, a-MCI+ subjects had the most compromised working memory and attention function. These results support previous findings that suggest a-MCI+ more closely resembles early stage Alzheimer's disease and those with a-MCI+ may be at increased rate of future cognitive decline compared to those with other MCI subtypes.