CYATHIN - NEW ANTIBIOTIC COMPLEX PRODUCED BY CYATHUS-HELENAE
CYATHIN - NEW ANTIBIOTIC COMPLEX PRODUCED BY CYATHUS-HELENAE
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DOI：
10.1139/m71-223
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发表时间：
1971-01-01
影响因子：
2.8
通讯作者：
TAUBE, H
中科院分区：
文献类型：
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作者：
ALLBUTT, AD;AYER, WA;TAUBE, H
真菌Cyathus helenaeBrodie（Gasteromycetes）产生一种抗生素物质复合物，统称为cyathin。当真菌在静态培养中在化学成分确定的液体培养基上在室温下生长25天时获得最高产量。通过将载有杯状蛋白的纸盘置于接种有待测微生物的琼脂平板上，测定杯状蛋白（及其组分）的作用光谱。蛋蓝蛋白复合物对放线菌、细菌（革兰氏阳性和革兰氏阴性）和一些真菌（包括皮肤真菌）具有活性。C.striatus（Huds.）Willd.例如，PoeppigiiL.，andC.limbatusL.从该复合物中分离出7种不同的化合物：2，4，5-三羟基苯甲醛（C7 H6 O 4）、cyathin A3（C20 H30 O3）、cyathin A4（C20 H30 O 4）、allocyathinA 4（C20 H30 O 4）、cyathin B3（C20 H28 O3）、cyathin B4（C20 H28 O 4）和cyathin C5（C20 H26 O 5）。除了2，4，5-三羟基苯甲醛之外，这些化合物似乎以前没有描述过。本文讨论了cyathin A_4和cyathin A_3的一些结构特征
The fungusCyathus helenaeBrodie (Gasteromycetes) produces a complex of antibiotic substances collectively called cyathin. Highest yields were obtained when the fungus was grown at room temperature for 25 days on a chemically defined liquid medium in static culture. The action spectrum of cyathin (and its components) was determined by placing cyathin-bearing paper discs on agar plates seeded with the microorganisms being tested. The cyathin complex is active against actinomycetes, bacteria (gram-positive as well as gram-negative), and some fungi, including dermatophytes. Weaker antimicrobial activity is also shown byC.striatus(Huds.) Willd. ex Pers.,C.poeppigiiL., andC.limbatusL. Seven different compounds have been isolated from the cyathin complex: 2,4,5-trihydroxybenzaldehyde (C7H6O4),cyathin A3(C20H30O3), cyathin A4(C20H30O4),allocyathinA4(C20H30O4),cyathin B3(C20H28O3), cyathin B4(C20H28O4), and cyathin C5(C20H26O5). Aside from 2,4,5-trihydroxybenzaldehyde, these compounds appear not to have been previously described. A discussion of some of the structural features of cyathin A4and cyathin A3is presented