Is there a sex-related difference in intragastric acidity and plasma gastrin concentration?
Is there a sex-related difference in intragastric acidity and plasma gastrin concentration?
复制标题
胃内酸度和血浆胃泌素浓度是否存在性别相关差异？
DOI：
10.1042/cs0820595
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Hobsley,M
中科院分区：
文献类型：
--
作者：
Hobsley,M
我写这篇关于EJ Prewett， JTL Smith， C. U. Nwokolo， A. M. sawyer和RE . Pounder最近发表在《临床科学》杂志上的论文。Sci。1991;80年,619 - 24)(l)。众所周知，胃酸分泌与胃泌素分泌[2]呈反比关系。这篇论文表明，与男性相比，女性的胃内酸度较低，这一发现完全在意料之中。无论胃酸分泌模式是双组分[3]还是后向扩散[4]，H+浓度都随着分泌速率的增加而升高，且男性的最大分泌量高于女性[5]。这种明显的性别差异是由于身高，而不是性别。在女性组（62公斤）的中位体重下，最大胃液分泌预计为244毫升/小时Vg（理想胃液），而男性组（74公斤）的最大胃液分泌为290毫升/小时Vg。用于进行这些计算的[5]中的方程见表2 (p. 558) no。3.(在我的计算中，假设所有的研究对象都不吸烟。Prewett等[11]只提供了23名女性受试者的吸烟数据，其中只有4名吸烟。似乎男性受试者吸烟的比例更大，鉴于已知的最大胃分泌量与过去吸烟总剂量之间的正相关关系，这可能会增加男性/女性的差异。)很多时候，分泌是基础的，而不是刺激的，同样的考虑也适用，但更有力，因为在低分泌水平下，非壁分泌的碱化作用和错误，如吞咽唾液和十二指肠胃反流，成比例地变得更大。根据[6]的数据，可以计算出女性在基础环境下的H+浓度（约10 mmol/l）代表约32 ml/ H Vg的分泌速率，而男性相应的H+浓度（约15 mmol/l）代表约35 ml/ H Vg的分泌速率。[我在[6]中使用的方程是Q/V= 0.134-1.04/V（由p. 135顶部的方程除以V得到；L =以mmol H+/I为单位的酸产量）。]我假定没有十二指肠胃反流，即苯酚红校正V= Vg。这些比率分别占相应最大比率的13%和12%，并不能支持本文提出的女性对高浓度胃泌素没有反应的假设。她们比男性产生的酸少，因为她们的身材较小，因此她们的胃液中H+的浓度也较小。
I write with respect to the paper by EJ Prewett, JTL Smith, C. U. Nwokolo, A. M. Sawyerr and RE Pounder published recently in Clinical Science (Clin. Sci. 1991; 80, 619-24)[l]. It is well known that there is an inverse relationship between gastric secretion of acid and gastrin secretion [2]. This paper demonstrates a low intragastric acidity in women compared with men, a finding that is entirely to be expected. Whether one’s model of gastric acid secretion is two-component [3] or back diffusion [4], H+ concentration rises as secretion rate increases, and men have a higher maximal secretion than women [5]. This apparent sex difference is due to stature, not gender [5]. At the median weight of the female group (62 kg), maximal gastric secretion is expected to be 244 ml/h Vg (ideal gastric juice) and at that of the male group (74 kg) 290 ml/h Vg. The equation in [5] used to make these calculations was that in Table 2 (p. 5 58) no. 3.(In my calculation it was assumed that none of the subjects smoked. Smoking data were given by Prewett et af.[11 only for 23 female subjects, of whom only four smoked. It seems likely that a larger proportion of male subjects smoked and this, in the light of the known positive correlations between maximal gastric secretion and total dose of cigarettes smoked in the past, would have probably increased the male/female discrepancy.) Much of the time, secretion was basal rather than stimulated and the same considerations apply, but rather more forcefully because at low levels of secretion the alkalinizing effect of non-parietal secretion and errors, such as swallowed saliva and duodenogastric reflux, become proportionately greater. From the data in [6], it can be calculated that the H+ concentration for women in basal circumstances (approximately 10 mmol/l) represents a secretion rate of about 32 ml/h Vg, whereas the corresponding H+ concentration for men (approximately 15 mmol/l) represents a secretion rate of about 35 ml/h Vg.[The equation I used in [6] is Q/V= 0.134-1.04/V (obtained by dividing the equation at the top of p. 135 by V; L,= acid output in mmol of H+/I). I assumed no duodenogastric reflux, ie Phenol Red-corrected V= Vg.] These rates represent respectively 13% and 12% of the corresponding maximal rates and lend no support to the hypothesis put forward in this paper that women fail to respond to high concentrations of gastrin. They make less acid than men because of their smaller stature, and their gastric secretion has a smaller H+ concentration for that reason.