Usefulness of cell-free and concentrated ascites reinfusion therapy in the therapeutic management of advanced ovarian cancer patients with massive ascites
Usefulness of cell-free and concentrated ascites reinfusion therapy in the therapeutic management of advanced ovarian cancer patients with massive ascites
复制标题
DOI：
10.1007/s10147-018-1371-7
复制
发表时间：
2019-04-01
影响因子：
3.3
通讯作者：
Fujii, Tomoyuki
中科院分区：
文献类型：
--
作者：
Kawata, Yoshiko;Nagasaka, Kazunori;Fujii, Tomoyuki
背景晚期卵巢癌(AOC)顽固性腹水的处理对于腹胀、呼吸窘迫和因大量腹水合并癌性腹膜炎而引起的食欲减退的患者至关重要。我们分析了浓缩腹水回输疗法(CART)在AOC治疗中的益处。方法回顾2011年1月至2017年3月接受CART治疗的AOC患者的记录。回顾分析患者治疗前后体重、腹围、尿量、血液成分、血压、心率、体温等生理指标的变化。通过测量CART前腹水肿瘤细胞(ATC)群的平均数目，探讨CART的临床病理意义。结果对29例AOC合并大量腹水患者47次CART治疗进行了回顾性分析。患者平均年龄56.612.8岁，平均疗程1.7+/-1.2次。平均处理腹水2,937+/-820毫升，浓缩至272+/-84毫升，平均含蛋白质85.0+/-33.2克。腹围显著减少(-5.30+/-0.65 cm；p
Background The management of refractory ascites in advanced ovarian cancer (AOC) is vital for patients with abdominal distention, respiratory distress, and anorexia due to massive ascites with cancer peritonitis. We analyzed the benefits of concentrated ascites reinfusion therapy (CART) in the management of AOC.Methods We reviewed records of AOC patients who underwent CART between January 2011 and March 2017. We retrospectively analyzed patients' backgrounds and physiological changes, including body weight, abdominal girth, urine volume, blood component values, blood pressure, heart rate, and body temperature before and after CART. We investigated the clinicopathological significance of CART by measuring the mean number of ascites tumor cell (ATC) clusters before CART.Results A retrospective analysis was performed on 29 cases of AOC with massive ascites involving 47 CART sessions. The patients' mean age was 56.612.8 years, and the mean number of sessions was 1.7 +/- 1.2. The mean volume of the processed ascites was 2,937 +/- 820mL, which was concentrated to 272 +/- 84mL containing 85.0 +/- 33.2g protein on average. Significant reductions in abdominal girth (-5.30 +/- 0.65cm; p