Variables associated with cognitive function in elderly California Seventh-day Adventists
Variables associated with cognitive function in elderly California Seventh-day Adventists
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DOI：
10.1093/oxfordjournals.aje.a008705
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发表时间：
1996-06-15
影响因子：
5
通讯作者：
Bennett, H
中科院分区：
文献类型：
--
作者：
Fraser, GE;Singh, PN;Bennett, H
1991 年，从一群白人、非西班牙裔加州基督复临安息日会信徒中随机选择了 99 名年龄超过 75 岁的受试者。饮食习惯和教育状况于1976年进行了测量。受试者于1991年完成了简易精神状态检查（MMSE），当时，他们或照顾者还提供了有关当前医疗问题和药物治疗的信息。那些在 1976 年摄入更多卡路里的人在 1991 年的 MMSE 分数较低（p = 0.03），通过在 1991 年排除既往中风或帕金森病的人，这种关联得到了加强。这提出了一种可能性，即中年时期摄入更多卡路里可能会加速随着衰老而出现的认知功能下降，正如在某些动物中明显发生的那样。受教育程度较低的受试者的 MMSE 分数较低，尤其是老年人。统计模型预测，精神药物的使用与 MMSE 评分 (p = 0.004) 之间的负相关关系在那些因其他原因而认知受损的人中尤其明显。如果存在因果关系，这表明医生应该非常谨慎地在此类受试者中使用这些药物。
From a cohort of white, non-Hispanic California Seventh-day Adventists, 99 subjects over age 75 years in 1991 were randomly selected. Dietary habits and educational status had been measured in 1976. Subjects completed the Mini-Mental State Examination (MMSE) in 1991, and at that time, they or caregivers also gave information on current medical problems and drug therapy. Those who ate more calories in 1976 had lower MMSE scores in 1991 (p = 0.03), an association strengthened by excluding those with previous stroke or Parkinson's disease by 1991. This raises the possibility that higher consumption of calories in middle age may accelerate the decline in cognitive function seen with aging, as apparently occurs in some animals. Less-educated subjects had lower MMSE scores, especially among the very elderly. The statistical model predicts that the negative association between use of psychotropic drugs and MMSE score (p = 0.004) is particularly potent in those cognitively impaired for other reasons. If causal, this suggests that physicians should use these agents very cautiously in such subjects.