LEAD-EXPOSURE AND THE CENTRAL AUDITORY PROCESSING ABILITIES AND COGNITIVE-DEVELOPMENT OF URBAN CHILDREN - THE CINCINNATI LEAD STUDY COHORT AT AGE 5 YEARS
LEAD-EXPOSURE AND THE CENTRAL AUDITORY PROCESSING ABILITIES AND COGNITIVE-DEVELOPMENT OF URBAN CHILDREN - THE CINCINNATI LEAD STUDY COHORT AT AGE 5 YEARS
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DOI：
10.1016/0892-0362(92)90028-9
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发表时间：
1992-01-01
影响因子：
2.9
通讯作者：
KEITH, RW
中科院分区：
文献类型：
--
作者：
DIETRICH, KN;SUCCOP, PA;KEITH, RW
该分析检查了辛辛那提队列（N = 259）5岁时全血（PbB）中登记的铅暴露与中枢听觉处理能力和认知发育状态之间的关系。虽然影响是小的，较高的产前，新生儿和出生后的PbB水平与较差的中央听觉处理能力的过滤字子测试的扫描（听觉处理障碍的筛选测试）。出生后较高的PbB水平与儿童考夫曼评估成套测验（K-ABC）中所有认知发育分量表的较差表现相关。然而，在调整家庭环境和母亲的智力措施后，几乎没有统计学或接近统计学显着的关联仍然存在。我们的研究结果进行了讨论的背景下的相关问题的混淆和检测的弱协会在高风险人群。
This analysis examined the relationship between lead exposure as registered in whole blood (PbB) and the central auditory processing abilities and cognitive developmental status of the Cincinnati cohort (N = 259) at age 5 years. Although the effects were small, higher prenatal, neonatal, and postnatal PbB levels were associated with poorer central auditory processing abilities on the Filtered Word Subtest of the SCAN (a screening test for auditory processing disorders). Higher postnatal PbB levels were associated with poorer performance on all cognitive developmental subscales of the Kaufman Assessment Battery for Children (K-ABC). However, following adjustment for measures of the home environment and maternal intelligence, few statistically or near statistically significant associations remained. Our findings are discussed in the context of the related issues of confounding and the detection of weak associations in high risk populations.