Antiinflammatory Sesquiterpenes from the Root Oil of Ferula hermonis
Antiinflammatory Sesquiterpenes from the Root Oil of Ferula hermonis
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DOI：
10.1002/ptr.3324
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发表时间：
2011-05-01
影响因子：
7.2
通讯作者：
Sarker, Satyajit D.
中科院分区：
文献类型：
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作者：
Geroushi, Afaf;Auzi, Abdurazag A.;Sarker, Satyajit D.
黑阿魏（伞形科），俗称“Shilsh-el-zallouh”，“Hashishat-al-kattira”或“黎巴嫩伟哥”，是一种小灌木，大量生长在叙利亚和黎巴嫩之间的赫尔蒙山。这种植物的种子和根在中东长期以来一直被用作春药，并用于治疗男性和女性的性冷淡和阳痿。通过角叉菜胶诱导的大鼠水肿模型，评估了从臭阿魏根油中分离的三种主要胡萝卜烷酯：阿魏苷（1）、替菲苷（2）和替菲苷（3）的抗水肿性质。在100 mg/kg的剂量下观察到1和2的抗炎作用，而化合物3没有显示出任何抗炎活性;相反，在角叉菜胶注射后2和3小时，它产生了显著的促炎作用。版权所有（C）2010约翰威利父子有限公司
Ferula hermonis Boiss. (Apiaceae), commonly known as 'Shilsh-el-zallouh', 'Hashishat-al-kattira' or 'The Lebanese viagra', is a small shrub that grows abundantly on the Hermon Mountain between Syria and Lebanon. The seeds and roots of this plant have long been used in the Middle East as an aphrodisiac, and for the treatment of frigidity and impotence for both men and women. The antiinflammatory properties of three major daucane esters, ferutinin (1) teferin (2) and teferidin (3), isolated from the root oil of Ferula hermonis, were assessed by the carrageenan-induced oedema model in rats. The antiinflammatory effect of both 1 and 2 was observed with a dose of 100 mg/kg, while compound 3 did not show any antiinflammatory activity; conversely it produced a significant proinflammatory effect 2 and 3 h after carrageenan injection. Copyright (C) 2010 John Wiley & Sons, Ltd.