A Japanese case of chronic lymphocytic leukemia with t (1;6).
A Japanese case of chronic lymphocytic leukemia with t (1;6).
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DOI：
10.1186/2162-3619-1-28
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发表时间：
2012-09-12
影响因子：
10.9
通讯作者：
Takeishi Y
中科院分区：
文献类型：
--
作者：
Harada K;Ikeda K;Matsumoto H;Furukawa M;Takahashi H;Ohkawara H;Noji H;Tasaki K;Abe M;Ogawa K;Takeishi Y
慢性淋巴细胞白血病（CLL）很少表现出侵袭性的临床病程，其患者通常有染色体缺失或增加。此外，在CLL中几乎没有观察到相互易位。只有少数报道具有t的CLL(1;6)，在这里，我们报告了亚洲第一例具有互易位t的CLL（1;6）。由于我们的病例和先前报道的t（1;6）的CLL患者一致表现出侵袭性临床病程，t（1;6）可能定义了一种不同类型的CLL。
Chronic lymphocytic leukemia (CLL) rarely exhibits an aggressive clinical course and its patients often have chromosomal deletions or additions. Furthermore, reciprocal translocations are barely observed in CLL. There have only been a few reports of CLL with t(1;6), and here we report the first Asian case of CLL with reciprocal translocation t(1;6). Since our case and previously reported CLL patients with t(1;6) consistently showed aggressive clinical course, t(1;6) may define a distinct type of CLL.