The effect of an education programme (MEDIAS 2 ICT) involving intensive insulin treatment for people with type 2 diabetes
The effect of an education programme (MEDIAS 2 ICT) involving intensive insulin treatment for people with type 2 diabetes
复制标题
DOI：
10.1016/j.pec.2011.05.017
复制
发表时间：
2012-02-01
影响因子：
3.5
通讯作者：
Haak, Thomas
中科院分区：
文献类型：
--
作者：
Hermanns, Norbert;Kulzer, Bernhard;Haak, Thomas
目的：在一项随机、多中心试验中，将涉及 2 型糖尿病患者强化胰岛素治疗的教育计划 (MEDIAS 2 ICT) 的效果与作为主动比较条件 (ACC) 的既定教育计划进行比较。方法：我们调查了 MEDIAS 2 ICT 在总体血糖控制方面是否不劣于 ACC。次要结果是糖尿病相关的痛苦、糖尿病知识、生活质量、自我护理行为、血脂、血压和体重。结果：186 名受试者被随机分组。六个月的随访后，ACC 中的平均 HbA1c 下降了 0.37%（从 8.2 +/- 1.1% 到 7.8 +/- 1.5%），MEDIAS 2 ICT 中的平均 HbA1c 下降了 0.63%（从 8.5 +/- 1.5% 到 7.9 +/- 1.2%）。两组之间的平均差异为 -0.26%（95% CI -0.63 至 -0.14），支持 MEDIAS 2 ICT。该结果在预定的非劣效性限度内。 MEDIAS 2 ICT (-3.4 +/- 7.1) 比 ACC (0.4 +/- 9.0; p = 0.31) 显着减少了与糖尿病相关的痛苦。结论：MEDIAS 2 ICT 在降低 HbA1c 方面与之前制定的教育计划一样有效，但在减少与糖尿病相关的痛苦方面表现出优越性。实际意义：MEDIAS 2 ICT 为 2 型糖尿病患者的教育提供了一种替代方案采用多次注射疗法进行治疗。 (C) 2011 Elsevier Ireland Ltd. 保留所有权利。
Objective: In a randomized, multi-centre trial, the effect of an education programme (MEDIAS 2 ICT) involving intensive insulin treatment for people with type 2 diabetes was compared with an established education programme as an active comparator condition (ACC).Methods: We investigated whether MEDIAS 2 ICT was non-inferior to ACC in overall glycaemic control. Secondary outcomes were the diabetes-related distress, diabetes knowledge, quality of life, self-care behavior, lipids, blood pressure and weight.Results: 186 subjects were randomized. After a six month follow-up the mean HbA1c decrease was 0.37% (from 8.2 +/- 1.1% to 7.8 +/- 1.5%) in the ACC and 0.63% (from 8.5 +/- 1.5% to 7.9 +/- 1.2%) in MEDIAS 2 ICT. The mean difference between both groups was -0.26% (95% CI -0.63 to -0.14) in favor of MEDIAS 2 ICT. This result was within the predefined limit for non-inferiority. Diabetes-related distress was significantly more reduced in MEDIAS 2 ICT (-3.4 +/- 7.1) than in ACC (0.4 +/- 9.0; p = 0.31).Conclusion: MEDIAS 2 ICT is as effective in lowering HbA1c as previously established education programmes, but showed superiority in reducing diabetes-related distress.Practical implications: MEDIAS 2 ICT provides an alternative for education of people with type 2 diabetes treated by multiple injection therapy. (C) 2011 Elsevier Ireland Ltd. All rights reserved.