Segregation of cortical head direction cell assemblies on alternating theta cycles
Segregation of cortical head direction cell assemblies on alternating theta cycles
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DOI：
10.1038/nn.3383
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发表时间：
2013-06-01
影响因子：
25
通讯作者：
Hasselmo, Michael E.
中科院分区：
文献类型：
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作者：
Brandon, Mark P.;Bogaard, Andrew R.;Hasselmo, Michael E.
用于空间导航的高级皮层系统，包括内嗅网格细胞，严重依赖于头部方向系统的输入。我们研究了参与头部方向网络的神经元之间的尖峰节律和同步模式，以寻找独立于直接感觉驱动的内部处理的证据，这可能对网格细胞功能很重要。我们发现，大鼠的头部方向网络被分成至少两组神经元，它们在交替的θ波周期（θ波周期跳跃）上放电，具有固定的同步或反同步关系。反同步θ周期跳变神经元对头部方向的调节差异较大，最小可达40度。中隔失活保留了头部方向信号，但消除了头部方向细胞的θ周期跳跃和网格细胞的空间周期性。我们提出头部方向网络中周期跳跃的内部机制可能对网格细胞的下游空间计算至关重要。
High-level cortical systems for spatial navigation, including entorhinal grid cells, critically depend on input from the head direction system. We examined spiking rhythms and modes of synchrony between neurons participating in head direction networks for evidence of internal processing, independent of direct sensory drive, which may be important for grid cell function. We found that head direction networks of rats were segregated into at least two populations of neurons firing on alternate theta cycles (theta cycle skipping) with fixed synchronous or anti-synchronous relationships. Pairs of anti-synchronous theta cycle skipping neurons exhibited larger differences in head direction tuning, with a minimum difference of 40 degrees of head direction. Septal inactivation preserved the head direction signal, but eliminated theta cycle skipping of head direction cells and grid cell spatial periodicity. We propose that internal mechanisms underlying cycle skipping in head direction networks may be critical for downstream spatial computation by grid cells.