Contribution of stroke volume to the change in pulse pressure pattern with age
Contribution of stroke volume to the change in pulse pressure pattern with age
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DOI：
10.1161/01.hyp.34.4.808
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发表时间：
1999-10-01
期刊：
影响因子：
8.3
通讯作者：
Cámera, MI
中科院分区：
文献类型：
--
作者：
Alfie, J;Waisman, GD;Cámera, MI
本研究调查了年龄对平均动脉压水平相同的未用药高血压男性的脉压的影响及其潜在机制。我们纳入了77名男性，年龄在17至76岁之间，白天平均动脉压在95至114 mm Hg之间。在仰卧位时，年轻人（30至40至49岁）的脉压显着扩大。然而，直立姿势消除了这种差异，通过更大的直立下降中风指数和脉压在最年轻的患者。50岁以后，尽管卒中指数进一步降低，但脉压仍呈进行性增宽。仰卧位、直立位和24小时脉压与年龄呈曲线相关（r分别为0.55，0.56和0.68，P
This study investigated the effect of age on pulse pressure and its underlying mechanisms in unmedicated hypertensive men with the same level of mean arterial pressure. We included 77 men 17 to 76 years old with daytime mean arterial pressure between 95 and 114 mm Hg. In the supine position, pulse pressure showed a significant widening in young (30 to 40 to 49 years. Upright posture, however, eliminated this difference through a larger orthostatic fall in stroke index and pulse pressure in the youngest patients. After age 50 years, pulse pressure exhibited a progressive widening despite the further age-related decrease in stroke index. Supine, upright, and 24-hour pulse pressure fitted a curvilinear correlation with age (r=0.55, 0.56, and 0.68, respectively, P