INTERFERON SUPPRESSES SYMPATHETIC NEURONAL CELL-DEATH CAUSED BY NERVE GROWTH-FACTOR DEPRIVATION
INTERFERON SUPPRESSES SYMPATHETIC NEURONAL CELL-DEATH CAUSED BY NERVE GROWTH-FACTOR DEPRIVATION
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DOI：
10.1111/j.1471-4159.1990.tb04155.x
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发表时间：
1990-08-01
影响因子：
4.7
通讯作者：
JOHNSON, EM
中科院分区：
文献类型：
--
作者：
CHANG, JY;MARTIN, DP;JOHNSON, EM
培养的大鼠交感神经元在剥夺神经生长因子后48小时内死亡。加入干扰素（IFN-α/.β的或IFN-γ）以剂量依赖性方式阻止细胞死亡。在较长时间的神经生长因子剥夺，干扰素未能维持生存。配体结合、放射自显影和交联实验证实了特异性IFN-γ的存在。交感神经元上的受体类似于在其他细胞类型上看到的受体。将干扰素的死亡抑制作用与干扰素的抗病毒或抗增殖作用机制进行比较。
Cultured rat sympathetic neurons die within 48 h after being deprived of nerve growth factor. Addition of interferons (IFN-.alpha./.beta. or IFN-.gamma.) prevented the cell death in a dose-dependent manner. Upon longer periods of nerve growth factor deprivation, IFNs failed to maintain survival. Thus, IFNs retarded neuronal death, but did not prevent it. Ligand binding, autoradiography, and cross-linking experiments demonstrated the presence of specific IFN-.gamma. receptors on sympathetic neurons similar to those seen on other cell types. The possible relationships of the death-suppressing actions of IFNs are compared to the mechanisms of the antiviral or antiproliferative actions of IFNs.