Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors
Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors
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DOI：
10.1271/bbb.70.774
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发表时间：
2006-04-01
影响因子：
1.6
通讯作者：
Fushiki, T
中科院分区：
文献类型：
--
作者：
Haramizu, S;Mizunoya, W;Fushiki, T
我们研究了辣椒素酯，一种非辛辣的天然辣椒素类似物，对小鼠在可调电流水池中游泳能力的影响。雄性BALB/c小鼠经口给予capsiate（10 mg/kg）后，在力竭前能保持较长的游泳时间。游泳30 min后，胶囊给药小鼠腓肠肌中的残留糖原较高，血清游离脂肪酸浓度有升高趋势，血清乳酸浓度显著降低。胶囊剂组的呼吸交换率的值在休息和跑步机跑步期间均显著较低。这些生理差异被取消的香草素受体拮抗剂，辣椒素（0.17 mmol/kg，腹腔注射）。在4小时的两瓶选择试验中，小鼠对辣椒素溶液没有反感。这些结果表明，口服辣椒素酯增强脂肪氧化和节省碳水化合物的利用，从而通过刺激其香草素受体增加小鼠的耐力游泳能力。预期capsiate的实际应用。
We investigated the effect of capsiate, a nonpungent natural capsaicin analog, on the swimming capacity of mice in an adjustable-current water pool. Male BALB/c mice orally given capsiate (10 mg/kg) were able to keep swimming longer before exhaustion than the control mice. After 30 min of swimming, the residual glycogen in the gastrocnemius muscle was higher, the serum free fatty acid concentration tended to be higher, and the serum lactic acid concentration was significantly lower in the capsiate-administered mice. The value for the respiratory exchange ratio of the capsiate group was significantly lower during both resting and treadmill running. These physiological differences were abolished by administering the vanilloid receptor antagonist, capsazepin (0.17 mmol/kg, i.p.). The mice were not averse to the capsiate solution during a 4-h two-bottle choice test. These results suggest that the oral administration of capsiate enhanced fat oxidation and spared carbohydrate utilization, and consequently increased the endurance swimming capacity of the mice via stimulation of their vanilloid receptors. Practical application of capsiate is expected.