Using F0F1-ATPase motors as micro-mixers accelerates thrombolysis
Using F0F1-ATPase motors as micro-mixers accelerates thrombolysis
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使用 F0F1-ATPase 电机作为微混合器可加速溶栓。
DOI：
10.1016/j.bbrc.2008.09.110
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发表时间：
2008-12-05
影响因子：
3.1
通讯作者：
Yue, Jiachang
中科院分区：
文献类型：
--
作者：
Tao, Ning;Cheng, Jie;Yue, Jiachang
我们开发了一种新型的微混合器使用生物分子ATP马达。微混合器由嵌入有色素细胞的无Δ F0 F1-ATP酶阵列构成，其中无Δ F1部分充当旋转器以混合溶液，而F0部分由光驱动。共聚焦显微镜研究表明，微混合器不直接接触FITC标记的纤维蛋白。由马达产生的纳米机械力诱导药物在溶液中运动并加速纤溶过程。所有结果都强烈表明，微混合器产生了纳米机械力，在较低浓度的蚓激酶存在下加速了纤维蛋白溶解过程。皇冠版权所有（C）2008由爱思唯尔公司出版。All rights reserved.
We have developed a novel micro-mixer using a biological molecular ATP motor. The micro-mixer was Constructed from arrays of chromatophore-embedded delta-free F0F1-ATPases, where the delta-free F-1 part acted as a rotator to Mix solutions, and the F-0 part was driven by light. Confocal microscope Studies indicated that the micro-mixer did not touch directly oil the fibrin labeled with FITC. The nanomechanical force generated by the motor induced drug movement in the solution and accelerated the fibrinolysis process. All results strongly Suggest that the micro-mixers generated a nanomechanical force which accelerated the fibrinolysis process in the presence of lower concentrations of lumbrokinase.. Crown Copyright (C) 2008 Published by Elsevier Inc. All rights reserved.